Featured Research

from universities, journals, and other organizations

Severe Psoriasis Associated With Increased Risk Of Death

Date:
December 17, 2007
Source:
JAMA and Archives Journals
Summary:
Patients with severe psoriasis appear to have an increased risk of death compared with patients without the skin condition, according to a new article. Psoriasis is a common inflammatory disorder that affects the skin and joints.

Patients with severe psoriasis appear to have an increased risk of death compared with patients without the skin condition, according to a new article.

Psoriasis is a common inflammatory disorder that affects the skin and joints, according to background information in the article. The condition has been associated with various other factors, including smoking, alcohol use and diseases such as obesity, cardiovascular disease and some cancers. "In addition, certain systemic therapies for psoriasis may rarely be associated with mortality [death] due to chronic cumulative drug toxicity or idiosyncratic reactions, and the disease itself may lead to death in rare instances," the authors write.

Joel M. Gelfand, M.D., M.S.C.E., and colleagues at the University of Pennsylvania School of Medicine, Philadelphia, analyzed records from a database of patients who visited general practitioners in the United Kingdom between 1987 and 2002. They identified 133,568 patients with mild psoriasis, defined as having a diagnosis of psoriasis but no history of treatment for the condition, and 3,951 patients with severe psoriasis, who did receive medications or other therapies. These patients were matched with up to five control patients who visited the same practice at around the same time but did not have psoriasis, including 560,358 matched to those with mild psoriasis and 15,075 matched to those with severe psoriasis.

During the study period, patients with severe psoriasis had a 50 percent increased risk of death compared with patients who did not have psoriasis (21.3 deaths per 1,000 individuals per year vs. 12 deaths per 1,000 individuals per year, respectively). Mild psoriasis was not associated with increased risk of death. Men with severe psoriasis died an average of 3.5 years younger than men without the condition, while women with severe psoriasis died 4.4 years earlier than women without psoriasis.

"Further studies are necessary to determine the cause of excess morality in patients with severe psoriasis, how the extent of skin disease affects morality risk and whether the risk of mortality in patients with severe psoriasis is altered by various systemic therapies," the authors conclude. "Patients with severe psoriasis should receive comprehensive health assessments to enhance preventive health practices, improve overall health and decrease the risk of mortality."

Journal reference: Arch Dermatol. 2007;143(12):1493-1499.

This study was supported by an unrestricted grant to the Trustees of the University of Pennsylvania from Centocor and a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Severe Psoriasis Associated With Increased Risk Of Death." ScienceDaily. ScienceDaily, 17 December 2007. <www.sciencedaily.com/releases/2007/12/071217162525.htm>.
JAMA and Archives Journals. (2007, December 17). Severe Psoriasis Associated With Increased Risk Of Death. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2007/12/071217162525.htm
JAMA and Archives Journals. "Severe Psoriasis Associated With Increased Risk Of Death." ScienceDaily. www.sciencedaily.com/releases/2007/12/071217162525.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins