Featured Research

from universities, journals, and other organizations

Improving Prognosis And Treatment Of Lung Cancer

Date:
January 8, 2008
Source:
Universitat Autonoma de Barcelona
Summary:
A specific enzyme can be detected in large quantities in lung cancers even when the cancer has not yet developed. Thus this molecule would serve as a good marker in the diagnosis and prognosis of the disease. The research is of great interest for potential future therapeutic applications as well.

A group of scientists led by Professor Xavier Parés of the Department of Biochemistry and Molecular Biology at Universitat Autònoma de Barcelona, has published new research on AKR1B10, an enzyme that is detected in large quantities only in lung cancers, particularly those caused by smoking. This enzyme can appear even when the cancer has not yet developed and lesions are precancerous.

Thus this molecule would serve as a good marker in the diagnosis and prognosis of the disease. Moreover, its activity could play a relevant role in the development of lung cancer, which makes the research of great interest for potential future therapeutical applications as well.

According to researchers, both the experiments using test tubes and cell cultures revealed that the enzyme lowers the levels of the most active form of vitamin A (retinoic acid), a strong anticancerous agent. This is achieved by its strong retinal reductase activity, which favours chemical reduction transformation, thus causing retinal, the precursor of retinoic acid, to transform into its least active form, retinol.

Retinoic acid is present in several biological processes - from fetus development to cell proliferation and differentiation - by controlling the expression of certain genes. The reduction of this acid within cells, which is precisely the effect produced by the enzyme under study, is linked directly to the lack of cell differentiation and therefore favours the development of the cancer. In order to discover why the enzyme acts this way, scientists obtained and studied its three-dimensional structure and located the elements responsible for its role in the onset of cancer among smokers.

The identification of these structural elements makes it possible to create a specific design for drugs that can treat this disease. In fact, researchers were able to observe how the substance tolrestat, used as an inhibitor of the enzyme AKR1B1, or aldose reductase, responsible for many secondary complications of diabetes, also worked to inhibit the activity of the enzyme AKR1B10. Since both enzymes contain similar structures, research was carried out on its possible applications in the treatment of diabetes.

The research, published in the American journal Proceedings of the National Academy of Sciences (PNAS), was directed by Xavier Parés and Jaume Farrés of the UAB Department of Biochemistry and Molecular Biology, with the collaboration of scientists from the Biomedical Research Institute of the Science Park of Barcelona (PCB), the Institute of Molecular Biology of Barcelona (CSIC), the Catalan Institute for Research and Advanced Studies (ICREA), and the Department of Organic Chemistry of the University of Vigo, Galicia.


Story Source:

The above story is based on materials provided by Universitat Autonoma de Barcelona. Note: Materials may be edited for content and length.


Cite This Page:

Universitat Autonoma de Barcelona. "Improving Prognosis And Treatment Of Lung Cancer." ScienceDaily. ScienceDaily, 8 January 2008. <www.sciencedaily.com/releases/2008/01/080107094922.htm>.
Universitat Autonoma de Barcelona. (2008, January 8). Improving Prognosis And Treatment Of Lung Cancer. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2008/01/080107094922.htm
Universitat Autonoma de Barcelona. "Improving Prognosis And Treatment Of Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/01/080107094922.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) — Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins