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Celiac Disease: Discovery Of Enzyme's Structure May Lead To New Treatments

Date:
January 9, 2008
Source:
American Chemical Society
Summary:
Researchers have discovered a new structure for a key enzyme associated with celiac disease, a finding that could lead to the design of new medications for the common digestive disorder. Celiac disease is a condition in which the stomach cannot properly digest wheat and other gluten-containing foods. The disease afflicts an estimated 2 million people in the United States alone.
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Researchers have discovered a new structure for a key enzyme associated with celiac disease, a finding that could lead to the design of new medications for the common digestive disorder, according to an article scheduled for the Jan. 7 issue of Chemical & Engineering News.

Celiac disease is a condition in which the stomach cannot properly digest wheat and other gluten-containing foods. The disease afflicts an estimated 2 million people in the United States alone.

In the article, C&EN Deputy Assistant Managing Editor Stu Borman notes that the disease is believed to occur when the protein gluten interacts with an enzyme called transglutaminase 2 (TG2), triggering an autoimmune reaction that damages the small intestine and causes diarrhea, abdominal pain and other symptoms. As a result, people with the disease are urged to follow a strict gluten-free diet.

Although scientists have previously obtained the X-ray crystal structure of human TG2, they have only revealed its "closed" or inactive form, the article points out. Now, Chaitan Khosla and colleagues at Stanford University report the first-ever determination of the "open" structure of the enzyme, in which its active site is accessible to substrates.

The finding that could help scientists design inhibitors of the enzyme that could serve as medications for celiac disease and other related conditions, according to the article.

Journal article: "Enzyme opens for business"


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The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


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American Chemical Society. "Celiac Disease: Discovery Of Enzyme's Structure May Lead To New Treatments." ScienceDaily. ScienceDaily, 9 January 2008. <www.sciencedaily.com/releases/2008/01/080107104321.htm>.
American Chemical Society. (2008, January 9). Celiac Disease: Discovery Of Enzyme's Structure May Lead To New Treatments. ScienceDaily. Retrieved July 3, 2015 from www.sciencedaily.com/releases/2008/01/080107104321.htm
American Chemical Society. "Celiac Disease: Discovery Of Enzyme's Structure May Lead To New Treatments." ScienceDaily. www.sciencedaily.com/releases/2008/01/080107104321.htm (accessed July 3, 2015).

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