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Discovery Major Step Forward In Treating Leukemia

Date:
January 20, 2008
Source:
University of East Anglia
Summary:
Researchers have discovered for the first time a pathway that makes cancerous leukemia cells resistant to treatment. The discovery is the first stage in the development of new drugs that could significantly improve survival rates for leukemia sufferers.
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Researchers at the University of East Anglia have discovered for the first time a pathway that makes cancerous leukaemia cells resistant to treatment.

The scientists found that death-resistant Acute Myeloid Leukaemia cells are given their resistance by a genetic anti-oxidant pathway called hemeoxygenase-1 or HO-1. This resistance pathway leads to relapse of the disease and non-responsiveness to treatments. When this pathway is inhibited, the cells lose their resistance and become responsive to death-inducing agents.

The discovery is the first stage in the development of new drugs that could significantly improve survival rates for leukaemia sufferers.

"This is a major step forward in the treatment of leukaemia and other cancers," said Prof David MacEwan who led the research team.

"The next step will be a programme to develop a new set of targeted therapies to treat not only Acute Myeloid Leukaemia, but other leukaemias and other cancers."

Leukaemia is one of the six biggest cancer killers in the UK and more people die of Acute Myeloid Leukaemia (AML) than any other form of leukaemia. AML attacks the white blood cells and is a common form in both children and adults with leukaemia. It is currently treated by a range of chemotherapy drugs. Many patients go on to have bone marrow transplants due to commonly developing drug-resistance to their initial chemotherapy.

The antioxidant response element (ARE) genes which include HO-1, protect cells from damage and their killing off by cytotoxic agents such as chemotherapy drugs. The team found that drug-resistant leukaemia cells have overactive ARE genes that cause them to be completely resistant to cytotoxic drugs, and that blocking this pathway reverts the cells into responding normally to cytotoxic agents.

This research is published online in the journal Blood on January 18.


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The above post is reprinted from materials provided by University of East Anglia. Note: Materials may be edited for content and length.


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University of East Anglia. "Discovery Major Step Forward In Treating Leukemia." ScienceDaily. ScienceDaily, 20 January 2008. <www.sciencedaily.com/releases/2008/01/080118093616.htm>.
University of East Anglia. (2008, January 20). Discovery Major Step Forward In Treating Leukemia. ScienceDaily. Retrieved July 31, 2015 from www.sciencedaily.com/releases/2008/01/080118093616.htm
University of East Anglia. "Discovery Major Step Forward In Treating Leukemia." ScienceDaily. www.sciencedaily.com/releases/2008/01/080118093616.htm (accessed July 31, 2015).

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