Featured Research

from universities, journals, and other organizations

Computer Model Developed For Osteoporosis Diagnostics

Date:
January 29, 2008
Source:
Vienna University of Technology
Summary:
Osteoporosis, a common age-related disease, is being investigated by a group of biomechanical engineers. In the frame of a clinical study, the evolution of vertebral bone density was monitored in patients. The researchers developed a simulation model, and computed the increase in bone strength on the basis of the measured bone density. Looking for the effect of Teriparatide medication, they demonstrated with the help of high-resolution CT images an increase in bone strength of up to 30%.

Model of damage to vertebral bone.
Credit: Image courtesy of Vienna University of Technology

Osteoporosis, a common age-related disease, is being investigated by a group of biomechanical engineers at Vienna University of Technology (TU Vienna). In the frame of a clinical study, the evolution of vertebral bone density was monitored in patients. The researchers developed a simulation model, and computed the increase in bone strength on the basis of the measured bone density. Looking for the effect of Teriparatide medication, they demonstrated with the help of high-resolution CT images an increase in bone strength of up to 30%.

Vienna (TU). Nowadays, information about bone density are obtained with the help of the DXA measurement method, where two low-intensity x-ray beams are sent through bones in the hip and in the lumbar spine. Based on the collected data, the World Health Organisation defines the degree of osteoporosis and predictions can be made about the risk of fracture. A new ‘anabolic’ medication, based on the recombinant human parathormone fragment Teriparatide, should help people suffering from an advanced stage of bone loss.

This anabolic treatment holds the promise of bone growth. “We were asked to monitor the mechanical effects of this growth over a period of two years by applying the finite element method to the recorded patient data. In collaboration with Prof. Claus Glόer of Schleswig-Holstein University Hospital, we used three-dimensional images from computer tomography to gain informations about the geometry and the material properties of the bone ”, explains Professor Philippe Kurt Zysset from the Institute of Lightweight Design and Structural Biomechanics at TU Vienna.

From such images, Zysset and his team develop mechanical models and simulate the mechanical behaviour of bones under various loading conditions. The reliability of these numerical simulations is continuously examined in the laboratory through biomechanical tests. Lilly, the international pharmaceutical company, used the results obtained by TU’s biomechanical engineers to interpret a two-year clinical study in which 44 patients were treated with Teriparatid products and bone growth was to be demonstrated.

Zysset says: “The patients’ thoracic vertebra T12 was examined using computer tomography before the start of treatment and after 6, 12 and 18 months,. This allowed us to calculate the change in vertebral strength, and we established that it has increased as a result of the treatment. This method provides more meaningful results than pure density measurements (DXA). After two years we demonstrated a mean increase of 30% in bone strength.”

Another medication, already available on the market for some time and known as an ‘antiresorptive’, employs the strategy of preventing or delaying bone loss in osteoporosis patients. There are plans to continue these investigations by comparing the effect of ‘antiresorptives’ with that of ‘anabolic’ drugs in patients with glucocorticoid-induced osteoporosis.


Story Source:

The above story is based on materials provided by Vienna University of Technology. Note: Materials may be edited for content and length.


Cite This Page:

Vienna University of Technology. "Computer Model Developed For Osteoporosis Diagnostics." ScienceDaily. ScienceDaily, 29 January 2008. <www.sciencedaily.com/releases/2008/01/080123175838.htm>.
Vienna University of Technology. (2008, January 29). Computer Model Developed For Osteoporosis Diagnostics. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2008/01/080123175838.htm
Vienna University of Technology. "Computer Model Developed For Osteoporosis Diagnostics." ScienceDaily. www.sciencedaily.com/releases/2008/01/080123175838.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) — Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins