Featured Research

from universities, journals, and other organizations

Targeting Gut Bugs Could Revolutionize Future Drugs, Say Researcher

Date:
February 4, 2008
Source:
Imperial College London
Summary:
Revolutionary new ways to tackle certain diseases could be provided by creating drugs which change the bugs in people's guts, according to a new article. Trillions of bugs known as gut microbes live symbiotically in the human gut. They play a key role in many of the processes that take place inside the body. Different people have different types of gut microbes living inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity.

Revolutionary new ways to tackle certain diseases could be provided by creating drugs which change the bugs in people's guts, according to a new article.

Related Articles


Trillions of bugs known as gut microbes live symbiotically in the human gut. They play a key role in many of the processes that take place inside the body. Different people have different types of gut microbes living inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity.

The authors of the Perspective argue that targeting gut microbes with new drug therapies, rather than concentrating on the mechanisms in the human body which are the current focus of most drug development programmes, could provide an array of uncharted possibilities for fighting disease. Much research is still needed to untangle the precise role played by each different type of bug.

Professor Jeremy Nicholson, one of the authors of the Perspective from the Department of Biomolecular Medicine at Imperial College London, explained: "It's only recently that we've discovered the huge influence that bugs in the gut have on people's health. The exciting thing about this is that it should be easier to create drugs that can change the bugs than it is to re-engineer human cells and signalling pathways inside the body. Also, if we're not interfering with the body's pathways, these drugs should have less toxic side-effects."

Research has already shown that the makeup of an individual's gut microbes is affected by their diet and other environmental factors. A recent study led by scientists from Imperial College showed that it is possible to alter the makeup of bugs in a mouse's gut, affecting their metabolism, using probiotics.

"We already know that external factors such as altering your diet can change the makeup of the bugs in your gut, so these kinds of therapies will mean a more holistic approach to medicine, looking not just at pharmaceutical treatments but also at lifestyle and nutrition. I think that in ten years' time it will be normal for scientists to take gut bugs into consideration when they are creating new medicines," added Professor Nicholson.

This work was published February 1 as a perspective article in the journal Nature Reviews Drug Discovery.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Targeting Gut Bugs Could Revolutionize Future Drugs, Say Researcher." ScienceDaily. ScienceDaily, 4 February 2008. <www.sciencedaily.com/releases/2008/02/080201093347.htm>.
Imperial College London. (2008, February 4). Targeting Gut Bugs Could Revolutionize Future Drugs, Say Researcher. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/02/080201093347.htm
Imperial College London. "Targeting Gut Bugs Could Revolutionize Future Drugs, Say Researcher." ScienceDaily. www.sciencedaily.com/releases/2008/02/080201093347.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins