Featured Research

from universities, journals, and other organizations

Gene Essential For Prenatal Development Of Nervous System Characterized

Date:
February 11, 2008
Source:
Stowers Institute for Medical Research
Summary:
Scientists have demonstrated the role of a gene important to the embryonic development of the nervous system, a process that requires coordination of differentiation of immature neural cells with the cycle of cell division that increases their numbers. Until now, the mechanisms regulating these distinct cellular activities have been poorly understood.

The Stowers Institute's Trainor Lab has demonstrated the role of a gene important to the embryonic development of the nervous system, a process that requires coordination of differentiation of immature neural cells with the cycle of cell division that increases their numbers. Until now, the mechanisms regulating these distinct cellular activities have been poorly understood.

Related Articles


In this work, the team used gain- and loss-of-function mutations in mice to isolate novel roles for the mouse Cux2 gene in regulating neurogenesis. They established that Cux2 directs neuroblast development, neuronal differentiation, and cell-fate determination in the spinal cord by coupling progression through the cycle of cell division with differentiation of neural cells by direct activation of two key neurogenic determinants, Neurod and p27Kipl.

"We were excited to uncover, for the first time, multiple functional roles for a Cux-like homeodomain transcription factor in regulating key aspects of spinal cord neurogenesis," said Angelo Iulianella, Ph.D., Senior Research Associate and first author on the publication. "The demonstration that Cux2 integrates cell-cycle progression with neural progenitor differentiation and cell-fate determination provides a much clearer picture of the complex process of neurogenesis."

"The impact of cell cycle length on the formation of interneurons versus motoneurons was a surprising finding," said Paul Trainor, Ph.D., Associate Investigator, and senior author on the publication. "Ongoing work involves global proteomic analyses aimed at identifying the complete set of Cux2-interacting partners. We believe these efforts will be essential to understanding how Cux2 elicits its multiple functions during neurogenesis."

Further analysis of Cux2 will make it possible to extend these findings not only to spinal cord development, but also to the mammalian cortex, where Cux genes demarcate specific upper layers of cortical neurons and may have played a role in the expansion and increased complexity of the cortex during evolution.

Journal reference: Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression...Iulianella et al. Development.2008; 135: 729-741Feb. 15, 2008.

Additional contributing authors to this publication include Madhulik Sharma, Ph.D., University of Kansas Medical Center Postdoctoral Fellow; Michael Durnin, Stowers Institute Research Specialist II; and Greg Vanden Heuvel, Ph.D., University of Kansas Medical Center Associate Professor of Anatomy and Cell Biology.


Story Source:

The above story is based on materials provided by Stowers Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Stowers Institute for Medical Research. "Gene Essential For Prenatal Development Of Nervous System Characterized." ScienceDaily. ScienceDaily, 11 February 2008. <www.sciencedaily.com/releases/2008/02/080201155700.htm>.
Stowers Institute for Medical Research. (2008, February 11). Gene Essential For Prenatal Development Of Nervous System Characterized. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2008/02/080201155700.htm
Stowers Institute for Medical Research. "Gene Essential For Prenatal Development Of Nervous System Characterized." ScienceDaily. www.sciencedaily.com/releases/2008/02/080201155700.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins