Featured Research

from universities, journals, and other organizations

Brain Circuitry That Drives Drug-seeking Compulsion Identified

Date:
February 7, 2008
Source:
Cell Press
Summary:
In experiments with rats, researchers have identified the change in brain circuitry that drives development of a compulsion to seek drugs, even when that compulsion is self-destructive. The researchers demonstrated the function of the circuitry by selectively switching off drug-seeking in the animals. They said their findings show the key role of the brain region, known as the striatum, which is a region activated by reward.

In experiments with rats, researchers have identified the change in brain circuitry that drives development of a compulsion to seek drugs, even when that compulsion is self-destructive. The researchers demonstrated the function of the circuitry by selectively switching off drug-seeking in the animals. They said their findings show the key role of the brain region, known as the striatum, which is a region activated by reward.

Related Articles


The researchers drew on previous studies indicating that when drug-seeking transforms from a goal-directed behavior to a compulsion, control over that behavior shifts from the ventral to dorsal region of the striatum. In their experiments, the researchers first trained rats to press a lever to obtain cocaine, which also activated a signal light. The researchers manipulated the schedule of cocaine-receiving and lever-pressing so that it would induce compulsive lever-pressing in the rats to obtain cocaine.

The researchers found that when they used surgery and drugs to sever the functional connection between the two striatal regions, the result was decreased drug-seeking behavior in rats, compared with rats in which the disconnection was not made.

In a second set of experiments, the researchers showed that the "disconnected" rats did not show reduced ability to acquire such training responses. Both normal and disconnected rats could learn to pull a chain to receive a sugar-water reward so long as the activity was continuously reinforced.

The researchers concluded that "The results of the present study demonstrate that intrastriatal connectivity is a key aspect of the functional organization of the striatum and also a critically important component of the complex neural mechanisms involved in the development of drug addiction."

Barry Everitt and David Belin published their findings in the February 7, 2008, issue of the journal Neuron, published by Cell Press.

The researchers include David Belin and Barry J. Everitt, of the Department of Experimental Psychology, University of Cambridge, Cambridge, UK.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Brain Circuitry That Drives Drug-seeking Compulsion Identified." ScienceDaily. ScienceDaily, 7 February 2008. <www.sciencedaily.com/releases/2008/02/080206121515.htm>.
Cell Press. (2008, February 7). Brain Circuitry That Drives Drug-seeking Compulsion Identified. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2008/02/080206121515.htm
Cell Press. "Brain Circuitry That Drives Drug-seeking Compulsion Identified." ScienceDaily. www.sciencedaily.com/releases/2008/02/080206121515.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins