Featured Research

from universities, journals, and other organizations

Ventilator Treatment Strategies Examined For Patients With Severe Respiratory Disorders

Date:
February 12, 2008
Source:
JAMA and Archives Journals
Summary:
A comparison of two treatment methods for critically ill patients with severe, rapid-onset lung disorders treated with mechanical ventilators found no significant difference in the risk of death, but did find that the newer method reduced the rates of severe persistent low oxygen levels and reduced the need for additional "rescue" therapies.

A comparison of two treatment methods for critically ill patients with severe, rapid-onset lung disorders treated with mechanical ventilators found no significant difference in the risk of death, but did find that the newer method reduced the rates of severe persistent low oxygen levels and reduced the need for additional "rescue" therapies, according to a new study.

Acute lung injury (such as from severe pneumonia or trauma) and acute respiratory distress syndrome (ARDS; the most serious form of acute lung injury), can be devastating complications of critical illness. Although mechanical ventilation provides essential life support, it can worsen lung injury. Low tidal volume (volume of air that is drawn with each breath) ventilation reduces the risk of death in critically ill patients with acute lung injury and ARDS. Adding therapies to effectively splint open collapsed lung segments may further reduce the risk of death, the authors write.

Maureen O. Meade, M.D., M.Sc., of Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada, and colleagues examined the effect on death of an experimental "lung open ventilation" (LOV) strategy combining low tidal volumes, recruitment maneuvers (periodic sighs on the ventilator to open the lung) and high levels of positive end-expiratory pressure (PEEP; to keep the lung open) compared with an established low-tidal-volume strategy (control group) in 983 patients with moderate and severe lung injury. The randomized trial (the LOV study) was conducted between August 2000 and March 2006 in 30 intensive care units in Canada, Australia and Saudi Arabia.

All-cause hospital death rates were 36.4 percent in the experimental group and 40.4 percent in the control group. Barotrauma rates (injury to the lung caused by the pressure of the ventilator) were 11.2 percent and 9.1 percent, respectively.

"... for patients with acute lung injury and ARDS, we found similar mortality in patients with a multi-faceted protocolized lung-protective ventilation strategy designed to open the lung compared with an established low-tidal-volume protocolized ventilation strategy. We found no evidence of significant harm or increased risk of barotrauma despite the use of higher PEEP. In addition, the 'open-lung' strategy appeared to improve oxygenation, with fewer hypoxemia-related deaths and a lower use of rescue therapies by the treating clinicians. Our results, in combination with the two other major trials, justify use of higher PEEP levels as an alternative to the established low-PEEP, low-tidal-volume strategy," the authors write.

Journal reference: JAMA. 2008;299[6]:637-645.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Ventilator Treatment Strategies Examined For Patients With Severe Respiratory Disorders." ScienceDaily. ScienceDaily, 12 February 2008. <www.sciencedaily.com/releases/2008/02/080212165423.htm>.
JAMA and Archives Journals. (2008, February 12). Ventilator Treatment Strategies Examined For Patients With Severe Respiratory Disorders. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/02/080212165423.htm
JAMA and Archives Journals. "Ventilator Treatment Strategies Examined For Patients With Severe Respiratory Disorders." ScienceDaily. www.sciencedaily.com/releases/2008/02/080212165423.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins