Featured Research

from universities, journals, and other organizations

How DDT Metabolite Disrupts Breast Cancer Cells

Date:
February 15, 2008
Source:
BioMed Central/Breast Cancer Research
Summary:
Research has shown that the main metabolite of the insecticide DDT could be associated with aggressive breast cancer tumors, but there has been no explanation for this observation to date. Now a new report shows how DDT could act to disrupt hormone-sensitive breast cancer cells.

Research has shown that the main metabolite of the insecticide DDT could be associated with aggressive breast cancer tumours, but there has been no explanation for this observation to date. Now a new report shows how DDT could act to disrupt hormone-sensitive breast cancer cells.

Michel Aube and colleagues from Universite Laval and Institut national de sante publique in Quebec, Canada have published findings suggesting that DDT''s main metabolite, 1,1- dichloro - 2,2 - bis(p-chlorophenyl)ethylene (p,p'-DDE), could increase breast cancer progression. They suggest a mechanism whereby p,p'-DDE opposes the androgen signalling pathway that inhibits growth in hormone-responsive breast cancer cells.

The team tested the effect of p,p'-DDE on the proliferation of CAMA-1 cells, a human breast cancer cell line that expresses the estrogen receptor alpha (ERa) and the androgen receptor (AR), either with or without physiological concentrations of estrogens and androgens. They also assessed p,p'-DDE-induced modifications in cell cycle entry and the expression of sex-steroid dependent genes including ESR1 and CCND1, the latter coding for a key protein involved in cell proliferation.

When estrogens and androgens were present in the cell culture medium, increasing concentrations of p,p'-DDE accelerated the growth of CAMA-1 breast cancer cells. p,p'-DDE had a similar effect on the proliferation of MCF7-AR1 cells, an estrogen responsive cell line genetically engineered to over express the AR. Adding the potent androgen dihydrotestosterone together with estradiol to the cell culture medium decreased the recruitment of CAMA-1 cells in the S phase and the expression of ESR1 and CCND1, by comparison with cells treated with estradiol alone. These androgen-mediated effects were blocked with similar efficacy by p,p'-DDE and the potent antiandrogen hydroxyflutamide.

'Our results suggest that in addition to estrogenic compounds, which have been the main focus of researchers over the past decades, chemicals that block the AR could favour breast cancer progression' says Pierre Ayotte, who is leading the research team.

Ayotte's team had previously linked concentrations of p,p'-DDE with tumour aggressiveness in women with breast cancer. They are now investigating the effect on breast cancer cell proliferation of a complex mixture of environmental chemicals, similar to that found in the blood of women, which comprises compounds with estrogenic and antiandrogenic activities.

Journal reference: 1,1 - dichloro - 2,2 - bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells. Michel Aube, Christian Larochelle and Pierre Ayotte. Breast Cancer Research (in press)


Story Source:

The above story is based on materials provided by BioMed Central/Breast Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central/Breast Cancer Research. "How DDT Metabolite Disrupts Breast Cancer Cells." ScienceDaily. ScienceDaily, 15 February 2008. <www.sciencedaily.com/releases/2008/02/080213193738.htm>.
BioMed Central/Breast Cancer Research. (2008, February 15). How DDT Metabolite Disrupts Breast Cancer Cells. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/02/080213193738.htm
BioMed Central/Breast Cancer Research. "How DDT Metabolite Disrupts Breast Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2008/02/080213193738.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins