Featured Research

from universities, journals, and other organizations

Building Brains: Mammalian-like Neurogenesis In Fruit Flies

Date:
February 24, 2008
Source:
BioMed Central/Neural Development
Summary:
A new way of generating brain cells has been uncovered in Drosophila. This novel mode of neurogenesis is very similar to that seen in mammalian brains, suggesting that key aspects of neural development could be shared by insects and mammals. In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically.

A new way of generating brain cells has been uncovered in Drosophila. The findings, published this week in the online open access journal Neural Development, reveal that this novel mode of neurogenesis is very similar to that seen in mammalian brains, suggesting that key aspects of neural development could be shared by insects and mammals.

In the widely accepted model of neurogenesis in Drosophila, neuroblasts divide asymmetrically both to self renew and to produce a smaller progenitor cell. This cell then divides into two daughter cells, which receive cell fate determinants, causing them to exit the cell cycle and differentiate.

In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically. A research team from the University of Basel, Switzerland set out to study whether specific Drosophila neural stem cells, neuroblasts, might increase the number of cells generated in the larval brain via a similar mechanism.

The team used cell lineage tracing and genetic marker analysis to show that surprisingly large neuroblast lineages are present in the dorsomedial larval brain -- a result, they say, of amplified neuroblast proliferation mediated through intermediate progenitors.

In the novel mechanism postulated by the researchers, there are intermediate progenitors present that divide symmetrically in terms of morphology, but asymmetrically in molecular terms. This latter feature means that cell fate determinants are segregated into only one daughter cell, leaving the other free to divide several more times, thus amplifying the number of cells generated.

The authors write: "The surprising similarities in the patterns of neural stem and intermediate progenitor cell division in Drosophila and mammals, suggest that amplification of brain neurogenesis in both groups of animals may rely on evolutionarily conserved cellular and molecular mechanisms."

Journal reference: Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Bruno C Bello, Natalya Izergina, Emmanuel Caussinus and Heinrich Reichert. Neural Development (in press)


Story Source:

The above story is based on materials provided by BioMed Central/Neural Development. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central/Neural Development. "Building Brains: Mammalian-like Neurogenesis In Fruit Flies." ScienceDaily. ScienceDaily, 24 February 2008. <www.sciencedaily.com/releases/2008/02/080218193923.htm>.
BioMed Central/Neural Development. (2008, February 24). Building Brains: Mammalian-like Neurogenesis In Fruit Flies. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/02/080218193923.htm
BioMed Central/Neural Development. "Building Brains: Mammalian-like Neurogenesis In Fruit Flies." ScienceDaily. www.sciencedaily.com/releases/2008/02/080218193923.htm (accessed April 19, 2014).

Share This



More Plants & Animals News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
Man Claims He Found Loch Ness Monster With... Apple Maps?

Man Claims He Found Loch Ness Monster With... Apple Maps?

Newsy (Apr. 18, 2014) Andy Dixon showed the Daily Mail a screenshot of what he believes to be the mythical beast swimming just below the lake's surface. Video provided by Newsy
Powered by NewsLook.com
First Ever 'Female Penis' Discovered In Animal Kingdom

First Ever 'Female Penis' Discovered In Animal Kingdom

Newsy (Apr. 18, 2014) Not only are these newly discovered bugs' sex organs reversed, but they also mate for up to 70 hours. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins