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Building Brains: Mammalian-like Neurogenesis In Fruit Flies

Date:
February 24, 2008
Source:
BioMed Central/Neural Development
Summary:
A new way of generating brain cells has been uncovered in Drosophila. This novel mode of neurogenesis is very similar to that seen in mammalian brains, suggesting that key aspects of neural development could be shared by insects and mammals. In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically.
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A new way of generating brain cells has been uncovered in Drosophila. The findings, published this week in the online open access journal Neural Development, reveal that this novel mode of neurogenesis is very similar to that seen in mammalian brains, suggesting that key aspects of neural development could be shared by insects and mammals.

In the widely accepted model of neurogenesis in Drosophila, neuroblasts divide asymmetrically both to self renew and to produce a smaller progenitor cell. This cell then divides into two daughter cells, which receive cell fate determinants, causing them to exit the cell cycle and differentiate.

In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically. A research team from the University of Basel, Switzerland set out to study whether specific Drosophila neural stem cells, neuroblasts, might increase the number of cells generated in the larval brain via a similar mechanism.

The team used cell lineage tracing and genetic marker analysis to show that surprisingly large neuroblast lineages are present in the dorsomedial larval brain -- a result, they say, of amplified neuroblast proliferation mediated through intermediate progenitors.

In the novel mechanism postulated by the researchers, there are intermediate progenitors present that divide symmetrically in terms of morphology, but asymmetrically in molecular terms. This latter feature means that cell fate determinants are segregated into only one daughter cell, leaving the other free to divide several more times, thus amplifying the number of cells generated.

The authors write: "The surprising similarities in the patterns of neural stem and intermediate progenitor cell division in Drosophila and mammals, suggest that amplification of brain neurogenesis in both groups of animals may rely on evolutionarily conserved cellular and molecular mechanisms."

Journal reference: Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Bruno C Bello, Natalya Izergina, Emmanuel Caussinus and Heinrich Reichert. Neural Development (in press)


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The above story is based on materials provided by BioMed Central/Neural Development. Note: Materials may be edited for content and length.


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BioMed Central/Neural Development. "Building Brains: Mammalian-like Neurogenesis In Fruit Flies." ScienceDaily. ScienceDaily, 24 February 2008. <www.sciencedaily.com/releases/2008/02/080218193923.htm>.
BioMed Central/Neural Development. (2008, February 24). Building Brains: Mammalian-like Neurogenesis In Fruit Flies. ScienceDaily. Retrieved May 29, 2015 from www.sciencedaily.com/releases/2008/02/080218193923.htm
BioMed Central/Neural Development. "Building Brains: Mammalian-like Neurogenesis In Fruit Flies." ScienceDaily. www.sciencedaily.com/releases/2008/02/080218193923.htm (accessed May 29, 2015).

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