Featured Research

from universities, journals, and other organizations

Gastric Acid May Help Protect Against Foodborne Diseases

Date:
February 26, 2008
Source:
American Society for Microbiology
Summary:
A new study suggests that low levels of gastric acid in the stomach can increase one's likelihood of getting a foodborne infection. The belief that gastric acid forms a barrier against bacterial pathogens is widespread among the healthcare community, however no previous experimental data has been reported. One of the three main functions ascribed to gastric acid is inhibiting infectious agents from reaching the intestine and distribution levels noted in fish, amphibians, reptiles, birds and mammals indicate evolutionary advantages.

A new study suggests that low levels of gastric acid in the stomach can increase one's likelihood of getting a foodborne infection.

The belief that gastric acid forms a barrier against bacterial pathogens is widespread among the healthcare community, however no previous experimental data has been reported. One of the three main functions ascribed to gastric acid is inhibiting infectious agents from reaching the intestine and distribution levels noted in fish, amphibians, reptiles, birds and mammals indicate evolutionary advantages.

Hypochlorhydria is a condition that occurs when gastric acid levels in the stomach are abnormally low and is commonly associated with increased risk of infection. In the study healthy mice and hypochlorhydric mice were infected with Yersinia enterocolitica, Salmonella enterica serovar Typhimurium, Citrobacter rodentium and Clostridium perfringens and then monitored for their ability to fight infection. Results showed that significantly higher numbers of all four pathogens survived in the hypochlorhydric mice. Further studies indicated that infected mice treated with antacids were more sensitive to infection due to the absence of stomach acid.

"Apart from establishing the role of gastric acid in nonspecific immunity to ingested bacterial pathogens, our model provides an excellent system with which to investigate the effects of hypochlorhydria on susceptibility to infection and to evaluate the in vivo susceptibility to gastric acid of orally administered therapies, such as vaccines and probiotics," say the researchers.

Journal reference: S.M. Tennant, E.L. Hartland, T. Phumoonna, D. Lyras, J.I. Rood, R.M. Robins-Browne, I.R. van Driel. 2008. Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infection and Immunity, 76. 2: 639-645.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Gastric Acid May Help Protect Against Foodborne Diseases." ScienceDaily. ScienceDaily, 26 February 2008. <www.sciencedaily.com/releases/2008/02/080221200040.htm>.
American Society for Microbiology. (2008, February 26). Gastric Acid May Help Protect Against Foodborne Diseases. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2008/02/080221200040.htm
American Society for Microbiology. "Gastric Acid May Help Protect Against Foodborne Diseases." ScienceDaily. www.sciencedaily.com/releases/2008/02/080221200040.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins