Featured Research

from universities, journals, and other organizations

How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered

Date:
February 26, 2008
Source:
European Molecular Biology Organization
Summary:
Scientists have solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month.

This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

Frédéric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme.

Their report reveals that the enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render them useless.

This explains why this type of enzyme is now carried by many bacteria struggling for survival in the antibiotic age.

More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.

Journal reference: Frédérique Maurice, Isabelle Broutin, Isabelle Podglajen, Philippe Benas, Ekkehard Collatz & Frédéric Dardel. Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. http://www.nature.com/embor/journal/vaop/ncurrent/abs/embor20089.html


Story Source:

The above story is based on materials provided by European Molecular Biology Organization. Note: Materials may be edited for content and length.


Cite This Page:

European Molecular Biology Organization. "How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered." ScienceDaily. ScienceDaily, 26 February 2008. <www.sciencedaily.com/releases/2008/02/080222101547.htm>.
European Molecular Biology Organization. (2008, February 26). How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2008/02/080222101547.htm
European Molecular Biology Organization. "How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/02/080222101547.htm (accessed August 23, 2014).

Share This




More Plants & Animals News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Endangered Red Wolves Face Uncertain Future

Endangered Red Wolves Face Uncertain Future

AP (Aug. 22, 2014) — A federal judge temporarily banned coyote hunting to save endangered red wolves, but local hunters say that the wolf preservation program does more harm than good. Meanwhile federal officials are reviewing its wolf program in North Carolina. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Farm Resurgence Grows With Younger Crowd

Farm Resurgence Grows With Younger Crowd

AP (Aug. 22, 2014) — New England farms are seeing a surge in younger farm hands as the 'buy local' food movement grows across the country. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) — According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins