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How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered

Date:
February 26, 2008
Source:
European Molecular Biology Organization
Summary:
Scientists have solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.
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A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month.

This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

Frédéric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme.

Their report reveals that the enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render them useless.

This explains why this type of enzyme is now carried by many bacteria struggling for survival in the antibiotic age.

More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.

Journal reference: Frédérique Maurice, Isabelle Broutin, Isabelle Podglajen, Philippe Benas, Ekkehard Collatz & Frédéric Dardel. Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. http://www.nature.com/embor/journal/vaop/ncurrent/abs/embor20089.html


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The above post is reprinted from materials provided by European Molecular Biology Organization. Note: Materials may be edited for content and length.


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European Molecular Biology Organization. "How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered." ScienceDaily. ScienceDaily, 26 February 2008. <www.sciencedaily.com/releases/2008/02/080222101547.htm>.
European Molecular Biology Organization. (2008, February 26). How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered. ScienceDaily. Retrieved August 30, 2015 from www.sciencedaily.com/releases/2008/02/080222101547.htm
European Molecular Biology Organization. "How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/02/080222101547.htm (accessed August 30, 2015).

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