Featured Research

from universities, journals, and other organizations

How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered

Date:
February 26, 2008
Source:
European Molecular Biology Organization
Summary:
Scientists have solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month.

Related Articles


This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

Frédéric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme.

Their report reveals that the enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render them useless.

This explains why this type of enzyme is now carried by many bacteria struggling for survival in the antibiotic age.

More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.

Journal reference: Frédérique Maurice, Isabelle Broutin, Isabelle Podglajen, Philippe Benas, Ekkehard Collatz & Frédéric Dardel. Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. http://www.nature.com/embor/journal/vaop/ncurrent/abs/embor20089.html


Story Source:

The above story is based on materials provided by European Molecular Biology Organization. Note: Materials may be edited for content and length.


Cite This Page:

European Molecular Biology Organization. "How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered." ScienceDaily. ScienceDaily, 26 February 2008. <www.sciencedaily.com/releases/2008/02/080222101547.htm>.
European Molecular Biology Organization. (2008, February 26). How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2008/02/080222101547.htm
European Molecular Biology Organization. "How Bacteria Gain Resistance To Multiple Types Of Antibiotics: Mechanism Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/02/080222101547.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Reuters - Innovations Video Online (Jan. 30, 2015) — A nanosensor that mimics the oral effects and sensations of drinking wine has been developed by Danish and Portuguese researchers. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Dog-Loving Astronaut Wins Best Photo of 2015

Dog-Loving Astronaut Wins Best Photo of 2015

Buzz60 (Jan. 30, 2015) — Retired astronaut and television host, Leland Melvin, snuck his dogs into the NASA studio so they could be in his official photo. As Mara Montalbano (@maramontalbano) shows us, the secret is out. Video provided by Buzz60
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) — The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Rarest Cat on Planet Caught Attacking Monkeys on Camera

Rarest Cat on Planet Caught Attacking Monkeys on Camera

Buzz60 (Jan. 30, 2015) — An African Golden Cat, the rarest large cat on the planet was recently caught on camera by scientists trying to study monkeys. The cat comes out of nowhere to attack those monkeys. Patrick Jones (@Patrick_E_Jones) has the rest. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins