Featured Research

from universities, journals, and other organizations

Of Mice And Men ... And Kidney Stones

Date:
March 4, 2008
Source:
Wiley-Blackwell
Summary:
Kidney stones are very common -- and painful -- in men. About 3 in 20 men (1 in 20 women) in developed countries develop them at some stage. Mice, however, rarely suffer though the precise reasons are unknown. Now researchers have come up with some answers.

Kidney stones are very common -- and painful -- in men. About 3 in 20 men (1 in 20 women) in developed countries develop them at some stage. Mice, however, rarely suffer though the precise reasons are unknown. Jeffrey S. Clark and colleagues, writing in The Journal of Physiology, have come up with some answers.

Related Articles


Kidney stones are crystalline deposits of various chemicals that should normally be excreted in the urine, particularly oxalate. Common in food, it is usually disposed of by the gut into the faeces by exchanging it for chloride. If there is little chloride available, in a low-salt diet for example, oxalate may be retained by the intestine to eventually be excreted by the kidneys, where the stones may form.

Mice, unlike men, do not spontaneously develop kidney stones, making it difficult to set up an animal model of this common disease. Now, some reasons for this difference between mice and men may have emerged.

The researchers showed that the human form of the protein responsible for secreting oxalate into the faeces requires a lot more chloride for efficient oxalate transport than the same structure in mice. Worse still, a variant form of the protein found in some people has even further reduced ability to export oxalate. Mice, it seems, are far more efficient at disposing of oxalate than we are.

Uncovering the molecular mechanisms of oxalate removal should help to develop improved treatments to prevent or even reverse the formation of kidney stones in humans, and paves the way for a mouse model of the disease to aid kidney stone research.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Of Mice And Men ... And Kidney Stones." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/03/080301081740.htm>.
Wiley-Blackwell. (2008, March 4). Of Mice And Men ... And Kidney Stones. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/03/080301081740.htm
Wiley-Blackwell. "Of Mice And Men ... And Kidney Stones." ScienceDaily. www.sciencedaily.com/releases/2008/03/080301081740.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins