Featured Research

from universities, journals, and other organizations

Of Mice And Men ... And Kidney Stones

Date:
March 4, 2008
Source:
Wiley-Blackwell
Summary:
Kidney stones are very common -- and painful -- in men. About 3 in 20 men (1 in 20 women) in developed countries develop them at some stage. Mice, however, rarely suffer though the precise reasons are unknown. Now researchers have come up with some answers.

Kidney stones are very common -- and painful -- in men. About 3 in 20 men (1 in 20 women) in developed countries develop them at some stage. Mice, however, rarely suffer though the precise reasons are unknown. Jeffrey S. Clark and colleagues, writing in The Journal of Physiology, have come up with some answers.

Kidney stones are crystalline deposits of various chemicals that should normally be excreted in the urine, particularly oxalate. Common in food, it is usually disposed of by the gut into the faeces by exchanging it for chloride. If there is little chloride available, in a low-salt diet for example, oxalate may be retained by the intestine to eventually be excreted by the kidneys, where the stones may form.

Mice, unlike men, do not spontaneously develop kidney stones, making it difficult to set up an animal model of this common disease. Now, some reasons for this difference between mice and men may have emerged.

The researchers showed that the human form of the protein responsible for secreting oxalate into the faeces requires a lot more chloride for efficient oxalate transport than the same structure in mice. Worse still, a variant form of the protein found in some people has even further reduced ability to export oxalate. Mice, it seems, are far more efficient at disposing of oxalate than we are.

Uncovering the molecular mechanisms of oxalate removal should help to develop improved treatments to prevent or even reverse the formation of kidney stones in humans, and paves the way for a mouse model of the disease to aid kidney stone research.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Of Mice And Men ... And Kidney Stones." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/03/080301081740.htm>.
Wiley-Blackwell. (2008, March 4). Of Mice And Men ... And Kidney Stones. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2008/03/080301081740.htm
Wiley-Blackwell. "Of Mice And Men ... And Kidney Stones." ScienceDaily. www.sciencedaily.com/releases/2008/03/080301081740.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins