Featured Research

from universities, journals, and other organizations

'Innocent Bystanders' Can Be The Cause Of Tumor Development

Date:
March 4, 2008
Source:
University of Helsinki
Summary:
Tumor growth has commonly been viewed as a result of mutations in a given cell that will therefore proliferate uncontrollably. However, a new study has demonstrated that in certain type of gastrointestinal polyps, the cause of tumor development are mutations in the smooth muscle cells, previously regarded as "innocent bystanders."

Tumor growth has commonly been viewed as a result of mutations in a given cell that will therefore proliferate uncontrollably. However, a study conducted at the University of Helsinki, Finland, has demonstrated that in certain type of gastrointestinal polyps, the cause of tumor development are mutations in the smooth muscle cells, previously regarded as "innocent bystanders".

Related Articles


The results emphasize the importance of interactions between tissue types, and open up possibilities to develop new treatment strategies targeting the intercellular signaling.

Gastrointestinal polyps are tumors that can both block the digestion and progress to cancer. The cell-type making up the bulk of the polyps and therefore responsible for the adverse effects are the hyper proliferating epithelial cells, which normally line the inner surface of the gastrointestinal tract. Therefore studies addressing the possible mechanisms of polyp development have traditionally focused on epithelial cells.

However, the results from professor Tomi Mไkelไ's research group demonstrate that origin of at least certain polyps is found elsewhere than in the pathologically growing epithelium. By restricting the mutations in mice to the smooth muscle cells that encircle the epithelium, researcher Pekka Katajisto discovered that deletion of the tumor suppressor gene Lkb1 leads to excessive proliferation of neighboring epithelial cells and tumor development.

The results demonstrate that Lkb1 deletion in smooth muscle cells disturbes the signaling between cells. Normally the smooth muscle cells appear to hold-back the proliferation of their neighboring epithelial cells by signals mediated by the growth factor TGF฿, but this signaling is reduced in the studied tumors. As a consequence, the epithelium undergoes accelerated proliferation. The same intercellular signaling defect was also noted in the Peutz-Jeghers polyposis caused by hereditary LKB1 mutations.

The study results has been published in Nature Genetics, online 2nd March, 2008.


Story Source:

The above story is based on materials provided by University of Helsinki. Note: Materials may be edited for content and length.


Cite This Page:

University of Helsinki. "'Innocent Bystanders' Can Be The Cause Of Tumor Development." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/03/080303093538.htm>.
University of Helsinki. (2008, March 4). 'Innocent Bystanders' Can Be The Cause Of Tumor Development. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2008/03/080303093538.htm
University of Helsinki. "'Innocent Bystanders' Can Be The Cause Of Tumor Development." ScienceDaily. www.sciencedaily.com/releases/2008/03/080303093538.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) — Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) — Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) — Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) — Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins