Featured Research

from universities, journals, and other organizations

'Innocent Bystanders' Can Be The Cause Of Tumor Development

Date:
March 4, 2008
Source:
University of Helsinki
Summary:
Tumor growth has commonly been viewed as a result of mutations in a given cell that will therefore proliferate uncontrollably. However, a new study has demonstrated that in certain type of gastrointestinal polyps, the cause of tumor development are mutations in the smooth muscle cells, previously regarded as "innocent bystanders."

Tumor growth has commonly been viewed as a result of mutations in a given cell that will therefore proliferate uncontrollably. However, a study conducted at the University of Helsinki, Finland, has demonstrated that in certain type of gastrointestinal polyps, the cause of tumor development are mutations in the smooth muscle cells, previously regarded as "innocent bystanders".

The results emphasize the importance of interactions between tissue types, and open up possibilities to develop new treatment strategies targeting the intercellular signaling.

Gastrointestinal polyps are tumors that can both block the digestion and progress to cancer. The cell-type making up the bulk of the polyps and therefore responsible for the adverse effects are the hyper proliferating epithelial cells, which normally line the inner surface of the gastrointestinal tract. Therefore studies addressing the possible mechanisms of polyp development have traditionally focused on epithelial cells.

However, the results from professor Tomi Mไkelไ's research group demonstrate that origin of at least certain polyps is found elsewhere than in the pathologically growing epithelium. By restricting the mutations in mice to the smooth muscle cells that encircle the epithelium, researcher Pekka Katajisto discovered that deletion of the tumor suppressor gene Lkb1 leads to excessive proliferation of neighboring epithelial cells and tumor development.

The results demonstrate that Lkb1 deletion in smooth muscle cells disturbes the signaling between cells. Normally the smooth muscle cells appear to hold-back the proliferation of their neighboring epithelial cells by signals mediated by the growth factor TGF฿, but this signaling is reduced in the studied tumors. As a consequence, the epithelium undergoes accelerated proliferation. The same intercellular signaling defect was also noted in the Peutz-Jeghers polyposis caused by hereditary LKB1 mutations.

The study results has been published in Nature Genetics, online 2nd March, 2008.


Story Source:

The above story is based on materials provided by University of Helsinki. Note: Materials may be edited for content and length.


Cite This Page:

University of Helsinki. "'Innocent Bystanders' Can Be The Cause Of Tumor Development." ScienceDaily. ScienceDaily, 4 March 2008. <www.sciencedaily.com/releases/2008/03/080303093538.htm>.
University of Helsinki. (2008, March 4). 'Innocent Bystanders' Can Be The Cause Of Tumor Development. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/03/080303093538.htm
University of Helsinki. "'Innocent Bystanders' Can Be The Cause Of Tumor Development." ScienceDaily. www.sciencedaily.com/releases/2008/03/080303093538.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins