Featured Research

from universities, journals, and other organizations

Tracking A Deteriorating Heart

Date:
March 10, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have conducted a detailed molecular survey of how heart muscle proteins change over time in diseased tissue, revealing clues that may lead to earlier diagnosis of heart disease.

Heart sections of normal and R9C mice reveal significant cardiac enlargement, even at the earliest time point.
Credit: Molecular and Cellular Proteomics

Researchers have conducted a detailed molecular survey of how heart muscle proteins change over time in diseased tissue, revealing clues that may lead to earlier diagnosis of heart disease.

Despite great progress in reducing mortality, cardiomyopathies (diseases affecting heart muscle) remain one of the leading killers in the developed world. A big contributor to this mortality is that many patients only get diagnosed at later disease stages, limiting therapeutic options.

Tony Gramolini, Andrew Emili and their colleagues sought to obtain more insight into cardiomyopathy progression, so they performed a large-scale protein survey of mouse cardiac cells affected by a mutation that weakens the muscle. They compared protein profiles at 8, 16, and 24 weeks of both diseased and healthy animals.

The researchers noticed time-dependent changes in 593 proteins, around 40 of which were particularly strong. While the altered proteins affect a variety of biological pathways, an inability to maintain the proper calcium balance, leading to increased cell stress, was heavily affected. Restoring this balance might be a key to treating these heart conditions early on.

This research was recently published in Molecular And Cellular Proteomics.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Tracking A Deteriorating Heart." ScienceDaily. ScienceDaily, 10 March 2008. <www.sciencedaily.com/releases/2008/03/080306154705.htm>.
American Society for Biochemistry and Molecular Biology. (2008, March 10). Tracking A Deteriorating Heart. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/03/080306154705.htm
American Society for Biochemistry and Molecular Biology. "Tracking A Deteriorating Heart." ScienceDaily. www.sciencedaily.com/releases/2008/03/080306154705.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins