Featured Research

from universities, journals, and other organizations

Bile Acids As Drug Candidates

Date:
March 19, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Bile acid derivatives can turn on the vitamin D receptor without causing excess calcium buildup, a finding that could lead to vitamin D therapies for conditions beyond just bone and skin disorders.

Derivatives of lithocholic acid can activate the same receptor as calcitriol, the active form of vitamin D, without affecting blood calcium levels.
Credit: Journal of Lipid Research

Bile acid derivatives can turn on the vitamin D receptor (VDR) without causing excess calcium buildup, researchers report, a finding that could lead to vitamin D therapies for conditions beyond just bone and skin disorders.

While calcium balance may be the most well-known role of vitamin D, this molecule --through VDR binding-- regulates many functions including immunity and cell growth and thus has diverse therapeutic potential.

However, while vitamin D-based drugs are effective against some cancers and microbial infections, the risk of excess blood calcium has limited their clinical use.

Bile acids, compounds secreted from the liver that aid in digestion, can also bind to the VDR, though not as strongly.

However, Makoto Makishima and colleagues found that derivates of the bile acid LCA (lithocolic acid) are very potent VDR activators. Interestingly, though, these acids did not induce the expression of calcium channels in various cell types.

The researchers then compared the effects of orally-fed vitamin D or LCA derivatives on mice; they found that LCA could promote VDR activation in mice without causing calcium buildup and weight loss that was observed in vitamin D animals. This study suggests bile acid derivates might have solid clinical potential.

This research was recently published in The Journal Of Lipid Research.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Bile Acids As Drug Candidates." ScienceDaily. ScienceDaily, 19 March 2008. <www.sciencedaily.com/releases/2008/03/080314165355.htm>.
American Society for Biochemistry and Molecular Biology. (2008, March 19). Bile Acids As Drug Candidates. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/03/080314165355.htm
American Society for Biochemistry and Molecular Biology. "Bile Acids As Drug Candidates." ScienceDaily. www.sciencedaily.com/releases/2008/03/080314165355.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins