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Salmonella Strains In Humans Distinct From Strains In Animals

Date:
March 27, 2008
Source:
American Society for Microbiology
Summary:
A new study suggests salmonella strains collected from human salamonellosis patients to be distinct from those of animal origin, a finding that could significantly impact the development of treatment methods for foodborne illnesses. Salmonella enterica, one of the most infectious foodborne pathogens inflicting humans today, is commonly transmitted through consumption of meat and food products that have been contaminated with animal waste.

A new study suggests salmonella strains collected from human salamonellosis patients to be distinct from those of animal origin, a finding that could significantly impact the development of treatment methods for foodborne illnesses.

Salmonella enterica, one of the most infectious foodborne pathogens inflicting humans today, is commonly transmitted through consumption of meat and food products that have been contaminated with animal waste. Currently over 2,300 types of S. enterica have been identified, and although useful epidemiologically, they provide limited information concerning bacterial diversity, evolutionary relatedness and pathogenicity. Virulence determinants and degree of pathogenicity in a particular animal host are not yet well understood.

In the study researchers tested the virulence capacities of 184 human and animal S. enterica isolates in mice. Results showed that all 21 serovar typhimurium isolates derived from animals were virulent in mice, while only 16 of 41 serovar typhimurium isolates collected from human salmonellosis patients were virulent. In contrast to all animal and human bacteremia samples tested, only 10 of 29 serovar typhimurium isolates from gastroenteritis patients were virulent. Lastly, among the serovar typhimurium isolates harboring virulent Salmonella, 6 of 31 from human salmonellosis patients were avirulent in mice, in direct contrast to the virulence exhibited by all the animal isolates studied.

"These studies suggest that Salmonella isolates derived from human salmonellosis patients are distinct from those of animal origin," say the researchers. "The characterization of these bacterial strain variants may provide insight into their relative pathogenicities as well as into the development of treatment and prophylactic strategies for salmonellosis."

Journal reference: D.M. Heithoff, W.R. Shimp, P.W. Lau, G.Badie, E.Y. Enioutina, R.A. Daynes, B.A. Byrne, J.K. House, M.J. Mahan. 2008. Human Salmonella clinical isolates distinct from those of animal origin. Applied and Environmental Microbiology, 74. 6: 1757-1766.


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The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


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American Society for Microbiology. "Salmonella Strains In Humans Distinct From Strains In Animals." ScienceDaily. ScienceDaily, 27 March 2008. <www.sciencedaily.com/releases/2008/03/080326181848.htm>.
American Society for Microbiology. (2008, March 27). Salmonella Strains In Humans Distinct From Strains In Animals. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/03/080326181848.htm
American Society for Microbiology. "Salmonella Strains In Humans Distinct From Strains In Animals." ScienceDaily. www.sciencedaily.com/releases/2008/03/080326181848.htm (accessed October 21, 2014).

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