Featured Research

from universities, journals, and other organizations

Reconstructing Mandibular Defects With Bioengineered Tooth And Bone

Date:
April 5, 2008
Source:
International & American Association for Dental Research
Summary:
Current strategies for jaw reconstruction require multiple procedures, first to repair the bone defect to offer sufficient support, and then to place the tooth implant. The entire procedure can be painful and time-consuming, and the desired aesthetic and functional repair can be achieved only when both steps are successful. Although the patient's quality of life can be improved significantly, the prognosis is often unpredictable, especially in young patients, whose jaws continue to grow, while the implant remains fixed.

Current strategies for jaw reconstruction require multiple procedures, first to repair the bone defect to offer sufficient support, and then to place the tooth implant. The entire procedure can be painful and time-consuming, and the desired aesthetic and functional repair can be achieved only when both steps are successful. Although the patient's quality of life can be improved significantly, the prognosis is often unpredictable, especially in young patients, whose jaws continue to grow, while the implant remains fixed.

The ability to bioengineer combined tooth and bone constructs, which would grow in a coordinated fashion with the surrounding tissues, could potentially improve the clinical outcomes, and also reduce patient suffering.

Under the guidance of Dr. Pamela C. Yelick, a research team at Tufts University (Boston, MA) has examined the feasibility of simultaneously reconstructing both teeth and bone. In 2002, the group first reported the regeneration of tooth crowns, from cultured tooth bud cells seeded onto biodegradable scaffolds and implanted into rat hosts. The morphology of the developing tissue-engineered tooth crowns closely resembled that of naturally formed teeth.

Next, they generated a hybrid tooth-bone construct, by combining a bone-marrow-derived stem-cell-seeded scaffold with the previously used tooth model, implanted and grown in the omenta (tissues connecting abdominal structures) of rat hosts. In this case, the formation of not only the tooth crowns but also tooth root and surrounding alveolar bone was observed. However, since the omentum offers an environment quite distinct from that of the natural tooth site, the jawbone, the team examined hybrid tooth-bone construct development using third molar tooth bud cells and bone marrow derived from, and implanted back into, the same minipig.

Their results showed the formation of organized bioengineered dental tissues closely resembling those of naturally formed teeth, including dentin, enamel, pulp, and periodontal ligament, after 12 weeks of implantation.

Further analyses confirmed the expression of tooth- and bone-specific markers on the bioengineered tissues. In addition, they observed novel mineralized tissue interface formation, including enamel/bone and dentin/bone interfaces. These results demonstrate the feasibility and therapeutic potential for regenerating tooth and bone from autologous stem cells, for craniofacial reconstructions in humans. This model is currently being modified to improve alveolar bone formation, regenerated dental tissue orientation, tooth root development, and tooth eruption.

This is a summary of abstract #1168, "Reconstructing Mandibular Defects with Autologous Bioengineered Tooth and Bone", by W. Zhang et al., of Tufts University, Boston, MA, USA, presented on April 5, 2008, during the 37th Annual Meeting of the American Association for Dental Research.


Story Source:

The above story is based on materials provided by International & American Association for Dental Research. Note: Materials may be edited for content and length.


Cite This Page:

International & American Association for Dental Research. "Reconstructing Mandibular Defects With Bioengineered Tooth And Bone." ScienceDaily. ScienceDaily, 5 April 2008. <www.sciencedaily.com/releases/2008/04/080405095752.htm>.
International & American Association for Dental Research. (2008, April 5). Reconstructing Mandibular Defects With Bioengineered Tooth And Bone. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2008/04/080405095752.htm
International & American Association for Dental Research. "Reconstructing Mandibular Defects With Bioengineered Tooth And Bone." ScienceDaily. www.sciencedaily.com/releases/2008/04/080405095752.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins