Featured Research

from universities, journals, and other organizations

Invention Gives Improved Gene Technology Analysis

Date:
April 27, 2008
Source:
Norwegian Institute of Public Health
Summary:
A newly patented invention from Norwegian researchers gives more reliable results in gene technology-based diagnostic tests. Previously, the state of the art was to use an unprotected internal control reagent to verify the validity of results. The problem was that it could only be added late in the analysis. The use of tailored coating of the internal control opens for, and enables presence of the control throughout the whole analytical process -- giving improved quality assurance.

A newly patented invention from Norwegian researchers gives more reliable results in gene technology-based diagnostic tests. Previously, the state of the art was to use an unprotected internal control reagent to verify the validity of results. The problem was that it could only be added late in the analysis. The use of tailored coating of the internal control opens for, and enables presence of the control throughout the whole analytical process -- giving improved quality assurance.

A patent for a system that gives more reliable results in gene technology-based diagnostic tests has been granted to researchers at the Norwegian Institute of Public Health (NIPH).

Gene technology analysis is used increasingly in diagnostic tests for detection of minute amounts of cells, bacteria and viruses in biological samples. However, false positive or negative results may occur.

"To uncover false negative results, an internal control reagent can be included in the tests to verify that the analysis results are valid. The problem with the internal controls used in today’s analyses is that they can only be added during, or at the end of the analysis process. This means that quality assurance is incomplete," explains Einar Sverre Berg at the Department for Virology.

Together with colleague Kjell Skaug he invented a protective shell for the internal control, based on cell/virus-mimicking liposomes. The liposome/internal control particles can thus be mixed with the biological test material when the sample is taken and be present during the entire analytical process. Whole process quality assurance is thereby achieved with more reliable results.

Chlamydia test first

Berg and Skaug were among the first in the world to show that restrictive substances in urine samples are an important source of false negative results in gene technology-based chlamydia tests. The scientists recognised the problem with incomplete quality assurance, and invented the solution for the tests.

"A fantastic property of the system is that it isn’t limited to just one test. It can be used in any gene technology-based assay detecting biologically substances. The liposome can be tailored and adapted according to the target – be it a virus or bacterium. The potential, in other words, is enormous," says Berg.

Berg and his colleague have applied for a patent on their discovery in all industrialised countries and have established the company IC Particles AS. Patents were first granted in New Zealand and Australia, followed by Norway. Berg is also optimistic about getting a patent in the USA within this year.


Story Source:

The above story is based on materials provided by Norwegian Institute of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Norwegian Institute of Public Health. "Invention Gives Improved Gene Technology Analysis." ScienceDaily. ScienceDaily, 27 April 2008. <www.sciencedaily.com/releases/2008/04/080424103222.htm>.
Norwegian Institute of Public Health. (2008, April 27). Invention Gives Improved Gene Technology Analysis. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2008/04/080424103222.htm
Norwegian Institute of Public Health. "Invention Gives Improved Gene Technology Analysis." ScienceDaily. www.sciencedaily.com/releases/2008/04/080424103222.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins