Featured Research

from universities, journals, and other organizations

New Study Shows How Genes Control Blood Proteins Important To Health

Date:
May 11, 2008
Source:
Public Library of Science
Summary:
A new study shows how genes control levels of many blood proteins implicated in disease. Newly published determine how many of the key proteins within our blood are under genetic control, showing that diet and lifestyle are not the only factors influencing its makeup.

A new study shows how genes control levels of many blood proteins implicated in disease. The findings are the result of an international collaboration between scientists at the University of Exeter, the National Institute on Aging, and the Tuscany and Florence Health Agencies. Newly published details determine how many of the key proteins within our blood are under genetic control, showing that diet and lifestyle are not the only factors influencing its makeup.

Related Articles


Maintaining the correct proportions of proteins, fats and other molecules in our blood is critical for normal health. An obvious example is cholesterol: high blood levels of "bad" LDL cholesterol and low blood levels of "good" HDL cholesterol increase the risk of heart disease. Previous studies have shown how cholesterol levels are not only influenced by diet and lifestyle but are also under strong genetic control.

This latest study, involving the entire genome, shows how blood levels of many other proteins are under strong genetic control. These proteins include a class of molecules called "interleukins" that are important in inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. Interleukins may also play a role in heart disease and related "metabolic" disorders. As an example, the group identified variations in genes that influence "Sex hormone binding globulin," a protein that controls how much testosterone is freely available in one's blood.

As another example, the group identified variations in genes that influence "Macrophage inflammatory protein beta" (MIP-beta), a protein that may play a role in influencing how likely people with HIV infection will go on to develop AIDS. The identification of these genes could lead to a greater understanding of the diseases they are implicated in.

"By identifying versions of genes that alter blood levels of important molecules we should be able to understand whether these molecules are important in disease processes or not," said Professor Tim Frayling, one of the study's leaders.

In this comprehensive study the researchers studied a total of 42 circulating proteins. The findings make way for future studies focusing on how the whole genome influences all proteins, not just those that end up circulating in the blood, although these are some of the most important from a disease perspective.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Melzer, John R. B. Perry, Dena Hernandez, Anna-Maria Corsi, Kara Stevens, Ian Rafferty, Fulvio Lauretani, Anna Murray, J. Raphael Gibbs, Giuseppe Paolisso, Sajjad Rafiq, Javier Simon-Sanchez, Hana Lango, Sonja Scholz, Michael N. Weedon, Sampath Arepalli, Neil Rice, Nicole Washecka, Alison Hurst, Angela Britton, William Henley, Joyce van de Leemput, Rongling Li, Anne B. Newman, Greg Tranah, Tamara Harris, Vijay Panicker, Colin Dayan, Amanda Bennett, Mark I. McCarthy, Aimo Ruokonen, Marjo-Riitta Jarvelin, Jack Guralnik, Stefania Bandinelli, Timothy M. Frayling, Andrew Singleton, Luigi Ferrucci, Vivian G. Cheung. A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs). PLoS Genetics, 2008; 4 (5): e1000072 DOI: 10.1371/journal.pgen.1000072

Cite This Page:

Public Library of Science. "New Study Shows How Genes Control Blood Proteins Important To Health." ScienceDaily. ScienceDaily, 11 May 2008. <www.sciencedaily.com/releases/2008/05/080508222414.htm>.
Public Library of Science. (2008, May 11). New Study Shows How Genes Control Blood Proteins Important To Health. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2008/05/080508222414.htm
Public Library of Science. "New Study Shows How Genes Control Blood Proteins Important To Health." ScienceDaily. www.sciencedaily.com/releases/2008/05/080508222414.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins