Featured Research

from universities, journals, and other organizations

Electrode Re-implantation Helps Some Parkinson's Disease Patients

Date:
May 13, 2008
Source:
JAMA and Archives Journals
Summary:
A study of seven patients with Parkinson's disease suggests that those who have poor results following implantation of electrodes to stimulate the brain may benefit from additional surgery to correct the electrode placement, according to a new report.

A study of seven patients with Parkinson's disease suggests that those who have poor results following implantation of electrodes to stimulate the brain may benefit from additional surgery to correct the electrode placement, according to a new report.

Related Articles


Implanting electrodes that stimulate the subthalamic nucleus, a region deep in the brain potentially related to impulsivity, is effective in reducing medication doses and improving the symptoms of Parkinson's disease, according to background information in the article. With this treatment, medication doses are often reduced by 50 percent to 65 percent, and scores on scales measuring motor function (generally impaired in Parkinson's disease) typically improve by 40 percent to 70 percent. However, sometimes the surgery is less effective.

"The principal cause of these poor results arises from imprecision of electrode placement, leading to non-stimulation of the target as required," the authors write. "Misplacement of the electrode by only a few millimeters may have occurred."

Mathieu Anheim, M.D., of the University Hospital A. Michallon, Strasbourg, France, and colleagues studied seven consecutive patients age 49 to 70 with Parkinson's disease who, despite electrode implantation, continued to experience severe symptoms. The patients were operated on again and the electrodes were re-implanted 12 to 23 months after the original surgery. Motor scores and medication doses were assessed one year after the second procedure.

All patients except for one displayed improvement after the second surgery. When they were not on medication, treatment improved the patient's motor scores by 26.7 percent following the first operation and 59.4 percent following the second procedure. Their dose of levodopa, a medication treating Parkinson's disease, decreased from 1,202 milligrams to 534 milligrams. The average distance between the electrodes and the target point of stimulation--a location in the subthalamic nucleus identified by evaluating electrode placement in patients whose surgery was successful--decreased from 5.4 to 2 millimeters. The shorter this distance, the greater the patient's improvement in motor scores.

"Although appropriate patient selection is important for the desired surgical outcome, the key to marked improvement following subthalamic nucleus stimulation is optimal surgical technique for precise implantation of stimulation electrodes in the target. Although neurosurgeons aim to minimize shifts from the originally planned electrode positions, this does not exclude the possibility that inadequate surgical technique may be responsible for postoperative lack of benefit," the authors write. "Patients demonstrating poor response to subthalamic nucleus stimulation as a result of electrode misplacement can benefit from re-implantation in the subthalamic nucleus closer to the theoretical target."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arch Neurol. 2008;65[5]:612-616

Cite This Page:

JAMA and Archives Journals. "Electrode Re-implantation Helps Some Parkinson's Disease Patients." ScienceDaily. ScienceDaily, 13 May 2008. <www.sciencedaily.com/releases/2008/05/080512163842.htm>.
JAMA and Archives Journals. (2008, May 13). Electrode Re-implantation Helps Some Parkinson's Disease Patients. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2008/05/080512163842.htm
JAMA and Archives Journals. "Electrode Re-implantation Helps Some Parkinson's Disease Patients." ScienceDaily. www.sciencedaily.com/releases/2008/05/080512163842.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins