Featured Research

from universities, journals, and other organizations

Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer

Date:
May 14, 2008
Source:
American Association for Cancer Research
Summary:
Studying thousands of patients, Japanese researchers have found a strong link between tooth loss and increased risk of three cancers -- esophageal, head and neck, and lung. They suggest that preservation of teeth may decrease risk of developing these diseases.

Studying thousands of patients, Japanese researchers have found a strong link between tooth loss and increased risk of three cancers -- esophageal, head and neck, and lung. They suggest that preservation of teeth may decrease risk of developing these diseases.

In the May issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research, scientists from Aichi Cancer Center in Nagoya and Nagoya University Graduate School of Medicine speculate that bacterial infection and inflammation resulting from poor oral care that leads to tooth loss could also be driving development of these cancers. Periodontal disease is known to increase risk for stroke and heart disease.

"Tooth loss is a common consequence of chronic bacterial infection and may, therefore, serve as a surrogate for chronic infection and inflammation, which in turn may be important to the pathogenesis of cancer," said the study's lead author, Akio Hiraki, Ph.D., a researcher at the Aichi Cancer Center.

Researchers measured rates of 14 different cancers and rates of tooth loss in 5,240 cancer patients in Japan, and compared those rates among 10,480 matched cancer-free participants. The researchers specifically found that people with tooth loss were 136 percent more likely to develop esophageal cancer, had a 68 percent increased risk of developing head and neck cancer and a 54 percent greater chance of developing lung cancer. The researchers also found that the rate of cancer increased proportionally to the number of teeth a patient had lost.

These increased risks were seen after researchers took into account a patient's history of smoking and alcohol use.

Smaller studies have linked tooth loss to different cancers, but this is the largest study to date, and the first conducted within an Asian population, the researchers say. This is also the first study to show a link to lung cancer, they add.

The researchers noted that age and gender affected the associations between tooth loss and cancer risk. For head and neck and esophageal cancers, there were clear associations between tooth loss and cancer risk in women and patients younger than 70 years old, but a less clear link in men and older patients.

The researchers say that while widespread inflammation could explain the link between tooth loss and cancer risk, they also note that tooth loss in the cancer patients may simply reflect unhealthy behaviors that contribute to cancer risk. Furthermore, people who have lost teeth may not be able to eat a healthy diet, and diet is also a factor in cancer development.

Whatever the mechanism, the researchers stress that oral care is critical to good health.

"The oral cavity is a gateway between the external environment and the gastrointestinal tract and acts in both food ingestion and digestion," the researchers wrote. "Oral hygiene potentially affects gastrointestinal flora and nutritional status and may thus have implications for the development of chronic disease."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer." ScienceDaily. ScienceDaily, 14 May 2008. <www.sciencedaily.com/releases/2008/05/080514064925.htm>.
American Association for Cancer Research. (2008, May 14). Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2008/05/080514064925.htm
American Association for Cancer Research. "Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/05/080514064925.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins