Featured Research

from universities, journals, and other organizations

Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer

Date:
May 14, 2008
Source:
American Association for Cancer Research
Summary:
Studying thousands of patients, Japanese researchers have found a strong link between tooth loss and increased risk of three cancers -- esophageal, head and neck, and lung. They suggest that preservation of teeth may decrease risk of developing these diseases.

Studying thousands of patients, Japanese researchers have found a strong link between tooth loss and increased risk of three cancers -- esophageal, head and neck, and lung. They suggest that preservation of teeth may decrease risk of developing these diseases.

In the May issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research, scientists from Aichi Cancer Center in Nagoya and Nagoya University Graduate School of Medicine speculate that bacterial infection and inflammation resulting from poor oral care that leads to tooth loss could also be driving development of these cancers. Periodontal disease is known to increase risk for stroke and heart disease.

"Tooth loss is a common consequence of chronic bacterial infection and may, therefore, serve as a surrogate for chronic infection and inflammation, which in turn may be important to the pathogenesis of cancer," said the study's lead author, Akio Hiraki, Ph.D., a researcher at the Aichi Cancer Center.

Researchers measured rates of 14 different cancers and rates of tooth loss in 5,240 cancer patients in Japan, and compared those rates among 10,480 matched cancer-free participants. The researchers specifically found that people with tooth loss were 136 percent more likely to develop esophageal cancer, had a 68 percent increased risk of developing head and neck cancer and a 54 percent greater chance of developing lung cancer. The researchers also found that the rate of cancer increased proportionally to the number of teeth a patient had lost.

These increased risks were seen after researchers took into account a patient's history of smoking and alcohol use.

Smaller studies have linked tooth loss to different cancers, but this is the largest study to date, and the first conducted within an Asian population, the researchers say. This is also the first study to show a link to lung cancer, they add.

The researchers noted that age and gender affected the associations between tooth loss and cancer risk. For head and neck and esophageal cancers, there were clear associations between tooth loss and cancer risk in women and patients younger than 70 years old, but a less clear link in men and older patients.

The researchers say that while widespread inflammation could explain the link between tooth loss and cancer risk, they also note that tooth loss in the cancer patients may simply reflect unhealthy behaviors that contribute to cancer risk. Furthermore, people who have lost teeth may not be able to eat a healthy diet, and diet is also a factor in cancer development.

Whatever the mechanism, the researchers stress that oral care is critical to good health.

"The oral cavity is a gateway between the external environment and the gastrointestinal tract and acts in both food ingestion and digestion," the researchers wrote. "Oral hygiene potentially affects gastrointestinal flora and nutritional status and may thus have implications for the development of chronic disease."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer." ScienceDaily. ScienceDaily, 14 May 2008. <www.sciencedaily.com/releases/2008/05/080514064925.htm>.
American Association for Cancer Research. (2008, May 14). Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/05/080514064925.htm
American Association for Cancer Research. "Tooth Loss Strongly Linked To Risk Of Esophageal, Head And Neck, And Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/05/080514064925.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins