Featured Research

from universities, journals, and other organizations

Noninvasive Oxygen Therapy Eases Final Hours, Days For Lung Cancer Patients

Date:
May 20, 2008
Source:
American Thoracic Society
Summary:
For patients with end-stage lung cancer, noninvasive ventilation may be more effective at reducing breathing difficulty than standard oxygen therapy, and has the added advantage of reducing patients' reliance on morphine, thus improving lucidity in their final days, according to new research. For patients at this stage, even small comforts can be the difference between a peaceful or an agonizing death.

For patients with end-stage lung cancer, noninvasive ventilation (NIV) may be more effective at reducing breathing difficulty than standard oxygen therapy, and has the added advantage of reducing patients' reliance on morphine, thus improving lucidity in their final days, according to research presented at the American Thoracic Society's 2008 International Conference in Toronto on Tuesday, May 20. For patients at this stage, even small comforts can be the difference between a peaceful or an agonizing death.

"With oxygen therapy you might improve oxygenation of the whole body with a small cannula inserted into the nose," explained Stefano Nava, M.D., chief of the respiratory critical care unit at Istituto Scientifico di Pavia in Italy, who led the research. "NIV implies the application of a face mask connected to ventilator. The main advantage over oxygen is that NIV not only improve oxygenation, but also the work of breathing."

This is the first research to compare the two therapies, and the first randomized controlled study to investigate the relief of respiratory distress in end-stage cancer patients. "It is surprising that in the literature there is nothing about the relief of respiratory distress in these end-stage cancer patients," said Dr. Nava. "The usual practice is giving standard oxygen therapy and/or morphine, but there is no evidence that these interventions work. This study may have important implications for both those patients and their families in the final, critical moments of their lives."

Dr. Nava and colleagues enrolled 92 patients who met the criteria and agreed to be randomized to receive either oxygen therapy or NIV. Three-month mortality for the groups were 89 and 87 percent respectively, and was not significantly different between the groups. Roughly a third of each patient group was discharged alive after an average of two weeks.

But while outcomes did not vary significantly, there were other striking differences: the researchers found that standard oxygen therapy took three hours to become effective, whereas NIV was able to relieve symptoms more quickly-- and after three hours, it remained as effective as standard therapy. Furthermore, the average use of morphine on the first 24 hours was significantly lower in the patients who received NIV.

"By using NIV, the need of morphine was reduced, and thus its side effects," explained Dr. Nava. "This means in addition to important physical benefits to the patients, there are also great potential benefits in the communication with caregivers and relatives."

"Keeping in mind that the patient should decide which treatment he or she would like, NIV may be proposed as an alternative treatment," he concluded. "In the subset of patients who could tolerate the treatment, NIV therapy may be an effective and more rapid treatment for improving dyspnea than standard oxygen therapy in end-stage cancer patients."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Noninvasive Oxygen Therapy Eases Final Hours, Days For Lung Cancer Patients." ScienceDaily. ScienceDaily, 20 May 2008. <www.sciencedaily.com/releases/2008/05/080520113309.htm>.
American Thoracic Society. (2008, May 20). Noninvasive Oxygen Therapy Eases Final Hours, Days For Lung Cancer Patients. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2008/05/080520113309.htm
American Thoracic Society. "Noninvasive Oxygen Therapy Eases Final Hours, Days For Lung Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2008/05/080520113309.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins