Featured Research

from universities, journals, and other organizations

Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease

Date:
June 1, 2008
Source:
American Society of Nephrology
Summary:
For patients with type 2 diabetes, a condition called non-alcoholic fatty liver disease may be an important risk factor for diabetes-related chronic kidney disease, according to a new study.

For patients with type 2 diabetes, a condition called non-alcoholic fatty liver disease (NAFLD) may be an important risk factor for diabetes-related chronic kidney disease (CKD), according to a study in the August Journal of the American Society of Nephrology (JASN).

"Identifying patients with NAFLD would highlight a subgroup of type 2 diabetic individuals who should be targeted with more intensive therapy to decrease their risk of developing CKD," comment lead authors Dr. Giovanni Targher of University of Verona in Verona, Italy and Dr. Michel Chonchol of University of Colorado Health Sciences Center in Denver, Colorado.

The relationship between NAFLD and CKD was studied in 1,760 Italian adult patients with type 2 diabetes. Non-alcoholic fatty liver is an increasingly common type of chronic liver disease, in which deposits of fat build up in the liver. Over time, NAFLD can progress to more advanced forms of liver disease, including cirrhosis. The study excluded patients with other common causes of fatty liver, such as alcohol abuse, chronic viral hepatitis and use of medications with potentially toxic effects on the liver.

All of the patients initially had normal or near-normal kidney function. During an average follow-up period of six and a half years, 547 patients developed CKD, with a yearly risk of about 4.5 percent.

The risk of CKD was elevated for patients with NAFLD--69 percent higher than for patients without NAFLD. The difference remained significant after adjustment for a wide range of other potential risk factors, including age and sex, body fatness, duration of diabetes, glycemic control, hypertension, smoking and medications for hypertension, diabetes or dyslipidemia.

This suggests that the link between NAFLD and CKD does not simply reflect shared risk factors for the two diseases (such as obesity). "Instead, NAFLD may be actively involved in the pathogenesis of CKD in type 2 diabetes, possibly through the release of some pathogenic factors from the liver," according to Drs. Targher and Chonchol. For example, the fatty liver might release certain substances that promote inflammation, thus contributing to diabetic kidney damage.

Diabetic nephropathy, or kidney disease, is a major complication of diabetes that can lead to end-stage renal disease (ESRD)--permanent loss of kidney function requiring dialysis or transplantation. "The treatment of earlier stages of nephropathy in diabetes is effective in slowing the progression toward ESRD," Drs Targher and Chonchol note. "Thus the early detection of precursors and risk factors of CKD is very important."

If confirmed by further research, the association between NAFLD and CKD may aid in identifying diabetic patients at increased risk of kidney disease. With intensive treatment, it might be possible to prevent or delay the development of CKD in these patients.

The authors point out some limitations of their study, including the use of an estimated measure of kidney function. Also, the presence of NAFLD was assessed by liver ultrasound, without biopsy to confirm the diagnosis. Further study is needed to determine whether fatty liver is linked to an increased risk of CKD in patients without diabetes and in nonwhite patients.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Targher et al. Increased Risk of CKD among Type 2 Diabetics with Nonalcoholic Fatty Liver Disease. Journal of the American Society of Nephrology, 2008

Cite This Page:

American Society of Nephrology. "Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease." ScienceDaily. ScienceDaily, 1 June 2008. <www.sciencedaily.com/releases/2008/05/080529162551.htm>.
American Society of Nephrology. (2008, June 1). Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2008/05/080529162551.htm
American Society of Nephrology. "Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2008/05/080529162551.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins