Featured Research

from universities, journals, and other organizations

Novel Chemo Drug Helps Treat Prostate Cancer

Date:
June 3, 2008
Source:
Oregon Health & Science University
Summary:
Men with a certain type of prostate cancer have been shown to respond to a new chemotherapy drug, sagopilone, plus prednisone in an international trial. The research involved men with androgen-independent prostate cancer that has metastasized, meaning their cancer has spread beyond the prostate and is not longer responding to hormonal therapies.

Men with a certain type of prostate cancer have been shown to respond to a new chemotherapy drug, Sagopilone, plus prednisone in an international trial led by Oregon Health & Science University Cancer Institute researchers.

The research involved men with androgen-independent prostate cancer that has metastasized, meaning their cancer has spread beyond the prostate and is not longer responding to hormonal therapies. This is the most advanced form of prostate cancer. Prostate cancer is the most common type of cancer in men in the United States, where it is responsible for more male deaths than any other cancer, except lung cancer.

"We are showing solid activity that this drug shows promise," said Tomasz Beer, M.D., principal investigator. He is the Grover C. Bagby Endowed Chair for Cancer Research, director of the Prostate Cancer Research Program at the OHSU Cancer Institute and associate professor of medicine (hematology/medical oncology), OHSU School of Medicine.

This research will be presented Saturday, May 31 at 8 a.m. at the annual American Association of Clinical Oncology in Chicago.

Of the 37 study participants taking the Sagopilone and prednisone long enough to be evaluated, the majority showed positive results in the reduction of their prostate specific antigens, or PSA. PSA is often elevated in the presence of prostate cancer.

During the three-month trial thirteen study participants had a more than 50 percent reduction in their PSA; 23 showed a 30 percent reduction; one who had radiographic measurable disease showed complete response; and four had unconfirmed prostate response. A 30 percent reduction in PSA levels in three months is a strong indicator of survival.

Sagopilone, a fully synthetic derivation, is a new class of drug that inhibits growth and the spread of malignant cell, similar to docetaxel, which has been the gold standard for this type of hormone independent prostate cancer. Docetaxel, however, it is not a cure and not all patients benefit from it. For this reason, Beer and colleagues are committed to searching for new drugs that will be effective against advanced prostate cancer.

"We look forward to completing this study and to the further investigation of Sagopilone as a new treatment option for men with advanced prostate cancer," said Beer.

The study was carried out in collaboration with members of the Prostate Cancer Clinical Trials Consortium, as well as a number of collaborating institutions in the United States and Argentina.

Research sites include: Blair Medical Associates, Altoona, Penn.; Portland Veterans Affairs Medical Center Billings Clinic, Billings, Mont.; Gabrail Cancer Center, Canton, Ohio; University of Nebraska Medical Center; University of Maryland Medical Center, Baltimore, Md.; Pacific Coast Hematology/Oncology Medical group, Fountain Valley, Calif.; Madigan Army Medical Center, Tacoma, Wash.; Veterans Affairs Puget Sound, Seattle, Wash.; John Peter Smith Center for Cancer care, Farmington, N.M.; Eastchester Center for Cancer Care., Bronx, N.Y.; University of Michigan Health System, An Arbor, Mich.; Florida Urology Specialists, Sarasota, Fla.; Hospital Privado Cordoba, Sanatorio Allende, both Cordoba, Argentina; Policlinica Bancaria, Hospital Alvarez, Hospital Durand and Hospital Britanico, all in Buenos Aires, Argentina.

Sagopilone is an experimental drug made by Bayer Healthcare Pharmaceuticals, which has funded this research.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Novel Chemo Drug Helps Treat Prostate Cancer." ScienceDaily. ScienceDaily, 3 June 2008. <www.sciencedaily.com/releases/2008/05/080530172628.htm>.
Oregon Health & Science University. (2008, June 3). Novel Chemo Drug Helps Treat Prostate Cancer. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2008/05/080530172628.htm
Oregon Health & Science University. "Novel Chemo Drug Helps Treat Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/05/080530172628.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins