Featured Research

from universities, journals, and other organizations

Mouse Ovaries And Testes Age In Unique Ways

Date:
June 8, 2008
Source:
BioMed Central
Summary:
Aging leads to large changes in gene activity in the ovaries of mice, but only limited changes in testes, according to new research. A lifespan-extending calorie-restricted diet reversed some of the aging effects -- but, unlike the widespread changes observed in somatic organs, it had an impact only in a small number of gonad-specific genes.

Aging leads to large changes in gene activity in the ovaries of mice, but only limited changes in testes, according to new research. A lifespan-extending calorie-restricted diet reversed some of the aging effects -- but, unlike the widespread changes observed in somatic organs, it had an impact only in a small number of gonad-specific genes.

Related Articles


As well as tackling one of the key questions of ageing -- by exploring if reproductive organs age in the same way as other body organs -- this research is important in the light of the trend for some women in developed countries to put off childbearing until later in life.

A research team led by Minoru Ko, MD, PhD, from the National Institute on Aging, Baltimore, USA used whole-genome DNA microarrays to study the effects of age, sex and diet on the global gene expression in mouse ovaries and testes. They found that reproductive organs age in a different way to other body tissues and, furthermore, that ovaries age in a different way from testes.

Age-related changes in gene expression occurred in gonads -- as they are known to in other body tissues -- but these changes tended to be in different classes of genes. Only two of the six categories of genes previously associated with aging in muscle, kidney and brain were associated with aging in the ovary; none were associated with aging in the testis. The changes seen in ovaries could be influenced by changes in the tissue composition of ovaries as females age and ovulation ceases.

The researchers also found that calorie restriction in females reduced the expression of genes involved in metabolism and follicle growth, which seems to be consistent with a popular view that the calorie restriction causes a shift in energy use away from reproduction towards general body maintenance and repair. However, male mice on the same diet did not appear to sacrifice reproductive function, suggesting an evolutionary difference between males and females when coping with a food shortage.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexei A Sharov, Geppino Falco, Yulan Piao, Suresh Poosala, Kevin G Becker, Alan B Zonderman, Dan L Longo, David Schlessinger and Minoru SH Ko. Effects of aging and calorie restriction on the global gene expression profiles of testis and ovary. BMC Biology, (in press)

Cite This Page:

BioMed Central. "Mouse Ovaries And Testes Age In Unique Ways." ScienceDaily. ScienceDaily, 8 June 2008. <www.sciencedaily.com/releases/2008/06/080602214128.htm>.
BioMed Central. (2008, June 8). Mouse Ovaries And Testes Age In Unique Ways. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2008/06/080602214128.htm
BioMed Central. "Mouse Ovaries And Testes Age In Unique Ways." ScienceDaily. www.sciencedaily.com/releases/2008/06/080602214128.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins