Featured Research

from universities, journals, and other organizations

Carbon Monoxide May Reduce Skeletal Muscle Injuries, Mouse Study Suggests

Date:
June 11, 2008
Source:
Society for Vascular Surgery
Summary:
Inhalation of carbon monoxide (CO) can reduce skeletal muscle injury after the following limb peripheral vascular disease (ischemia), where blood flow is interrupted and can be compounded by reperfusion, when damage is caused after the blood supply returns to the tissue. When this occurs, there can be limb loss or death.

Inhalation of carbon monoxide (CO) can reduce skeletal muscle injury after the following limb peripheral vascular disease (ischemia), where blood flow is interrupted and can be compounded by reperfusion, when damage is caused after the blood supply returns to the tissue. When this occurs, there can be limb loss or death.

Researchers from Massachusetts General Hospital in Boston reviewed the results of 23 mice from two groups: 10 who were given CO and 13 who were not, to determine how CO affects their recovery from such injuries.

“Mice that inhaled a low dose CO after an onset of ischemia resulted in decreased markers of inflammation locally in the injured skeletal muscle and systemically in the blood, and had increased energy levels after ischemia/reperfusion (I/R) mediated injury within the injured limb,” said Rajendra Patel, MD, clinical and research fellow in the department of vascular surgery.

“All of these factors may allow for a faster and more complete recovery in humans, and even decrease limb loss or death,” said Dr. Patel.

In the study, unilateral hind limb I/R was created using an orthodontic rubber band applied to 23 mouse limbs for 1.5 hours. Immediately after application of the band, during ischemia and the initial six hours of reperfusion, 10 mice were put in sealed chambers equilibrated with gases composed of 250 ppm CO mixed with room air.

The 13 other mice were put in a chamber of air alone.

After six hours reperfusion, all mice were placed in room air at ambient temperature and sacrificed after 24 hours. The I/R and the uninjured contralateral hind limbs were harvested for biochemical analysis and histologic evidence of tissue injury; the CO treated mice had less skeletal muscle injury compared to room air treated mice (a mean 16.8 percent vs. 29.2 percent). This group also had higher tissue ATP levels when compared to the control group (mean 21.9 vs. 8.0 contralateral) and serum and muscle KC levels were markedly reduced in the CO group when compared to the control group. There was no difference in mean blood pressure and heart rate in both groups of mice when measured at baseline, 6 and 24 hours reperfusion.

Dr. Patel noted that acute limb (I/R) injury is a prevalent clinical problem associated with significant morbidity and mortality, but therapeutic inhalation with CO has been shown to reduce I/R injury in lung, cardiac and hepatic tissue. He added that inhalation therapy with CO protects skeletal muscle from I/R injury independent of hemodynamic effects, and is associated with preserved skeletal muscle ATP, decreased fiber injury, and local and systemic levels of proinflammatory cytokines.

“Although CO is known to be a toxic and deadly gas at high concentrations, our findings support the role of low CO treatment in acute limb threatening ischemia, and our research may help patients in the future,” said Dr. Patel.

Results of their study were presented during the Vascular Annual Meeting, June 5-8, San Diego, Calif.


Story Source:

The above story is based on materials provided by Society for Vascular Surgery. Note: Materials may be edited for content and length.


Cite This Page:

Society for Vascular Surgery. "Carbon Monoxide May Reduce Skeletal Muscle Injuries, Mouse Study Suggests." ScienceDaily. ScienceDaily, 11 June 2008. <www.sciencedaily.com/releases/2008/06/080610185957.htm>.
Society for Vascular Surgery. (2008, June 11). Carbon Monoxide May Reduce Skeletal Muscle Injuries, Mouse Study Suggests. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2008/06/080610185957.htm
Society for Vascular Surgery. "Carbon Monoxide May Reduce Skeletal Muscle Injuries, Mouse Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610185957.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins