Featured Research

from universities, journals, and other organizations

Oily Fish Can Protect Against Rheumatoid Arthritis, But Smoking And Psychosocial Stress Increase Its Risk

Date:
June 15, 2008
Source:
European League Against Rheumatism
Summary:
New data show that intake of oily fish is associated with a reduced risk of developing rheumatoid arthritis, whereas psychosocial work stress and smoking can increase the risk of developing the condition. The findings, all taken from a large population-based case-control study in Sweden, shed light on the important role of environmental and social factors in the development of RA.

New data presented June 13 at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France, show that intake of oily fish is associated with a reduced risk of developing rheumatoid arthritis (RA), whereas psychosocial work stress and smoking can increase the risk of developing the condition.

Related Articles


The findings, all taken from a large population-based case-control study in Sweden called EIRA (Epidemiological Investigation of Rheumatoid Arthritis), shed light on the important role of environmental and social factors in the development of RA.

Intake of Oily Fish

For the first time, the intake of oily fish has been demonstrated to have a protective effect against the development of RA, reducing an individual's risk by 20-30%. Studying 1,899 subjects with a confirmed diagnosis of RA (fulfilling ACR criteria) and 2,145 controls (randomly selected and matched for age, sex and residential area), investigators concluded that the odds ratio (OR) for developing RA was 0.8 (0.7-1.0) for those who consumed oily fish 1-7 times per week or 1-3 times per month, compared with those who never, or seldom consumed oily fish. Interestingly, no significant association with RA risk was observed for consumption of fish oil supplements.

Smoking Dosage

Tobacco smoking is an established risk factor for RA, but the investigators found that there is a dose dependency for the level of smoking (i.e. the number of cigarettes smoked across a given period) on the odds ratio of developing anti-citrulline (anti-CCP) positive RA. The highest odds ratios were seen in those carrying a risk variant of the susceptibility gene PTPN22. In the study, 1,240 cases and 798 controls were identified as smokers from a total group of 1,419 cases and 1,674 controls via an extensive questionnaire regarding lifestyle factors, including smoking habits.

These subjects were then classified into three different groups according to the number of pack years smoked - less then 10, 10-20 or more than 20 pack years (where one pack-year is equivalent to having smoked one pack per day for one year) and genotyped to determine the presence of the PTPN22 risk allele.

Psychosocial Stress at Work

Psychosocial stress at work, defined as low decision latitude (or low level of control) was found to be associated with a higher risk for RA. Collected via a validated questionnaire, this was demonstrated in both self-reported data (OR=1.6 (95% CI 1.2-2.2)) and JEM (job exposure matrix)-derived data (OR=1.3 (95% CI 1.0-1.7)). These results were only marginally changed when the investigators adjusted the odds ratios for social class and smoking for the 1,221 cases and 1,454 controls who participated in the study.

Mrs Annmarie Wesley of the Institute of Environmental Medicine, Stockholm, Sweden, EIRA investigator and lead author of the oily fish intake study, commented: "The findings from these studies add to an increasing body of evidence to support the assertion that lifestyle modifications can have a significant impact on an individual's risk for developing RA, one of the most common autoimmune diseases, affecting approximately 1% of adults worldwide. We hope that the data will contribute to the growing understanding of the aetiology of RA and, ultimately, its treatment and prevention."


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Oily Fish Can Protect Against Rheumatoid Arthritis, But Smoking And Psychosocial Stress Increase Its Risk." ScienceDaily. ScienceDaily, 15 June 2008. <www.sciencedaily.com/releases/2008/06/080613111850.htm>.
European League Against Rheumatism. (2008, June 15). Oily Fish Can Protect Against Rheumatoid Arthritis, But Smoking And Psychosocial Stress Increase Its Risk. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2008/06/080613111850.htm
European League Against Rheumatism. "Oily Fish Can Protect Against Rheumatoid Arthritis, But Smoking And Psychosocial Stress Increase Its Risk." ScienceDaily. www.sciencedaily.com/releases/2008/06/080613111850.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Ebola Crisis Affecting US Adoptions

Ebola Crisis Affecting US Adoptions

AP (Nov. 20, 2014) The Sanborn family had hoped they'd be able to bring home their 5-year-old adopted son from Liberia by now. But Ebola has forced them to wait. The boy is just one of thousands of orphans in West Africa who've been impacted by the deadly virus. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins