Featured Research

from universities, journals, and other organizations

Potential Protein Biomarkers For Growth Hormone Identified

Date:
June 23, 2008
Source:
Ohio University
Summary:
Scientists have identified several proteins in mice that might act as biomarkers for growth hormone. The research could be the first step to finding a more reliable way to detect recombinant human growth hormone (rhGH), which some athletes and teenagers use illegally to in an effort to boost muscle and reduce fat.

Ohio University scientists have identified several proteins in mice that might act as biomarkers for growth hormone. The research could be the first step to finding a more reliable way to detect recombinant human growth hormone (rhGH), which some athletes and teenagers use illegally in an effort to boost muscle and reduce fat.

Related Articles


At the Endocrine Society annual meeting in San Francisco June 17, scientists John Kopchick and Juan Ding presented a new study that pinpointed four proteins that significantly decreased or increased in the blood after exposure to bovine growth hormone, which is similar to human growth hormone.

The researchers injected six 6-month-old male mice with growth hormone for seven days. They studied blood samples from the mice and compared the results to six control animals. Kopchick and Ding scanned hundreds of plasma proteins and found four -- apoA1, transthyretin, clusterin and albumin -- that showed a strong reaction to growth hormone.

"They're in the blood, but we don't know if they're coming from liver, fat, muscle or the kidneys," said Kopchick, Goll-Ohio Professor of Molecular Biology with Ohio University's Edison Biotechnology Institute and College of Osteopathic Medicine.

Kopchick and Ding, a graduate student in biological sciences, are hopeful that the proteins could be viable biomarkers for growth hormone activity in humans as well.

"In mice we can control the variables and the environment, but humans are genetically diverse and have different lifestyles that impact growth hormone. So the results may point to future study in humans, but may not necessarily apply to humans yet," said Ding, who also is studying how to identify protein biomarkers for human aging.

Growth hormone is hard to detect because it has a serum half life of only 15 minutes. RhGH, an approved drug for individuals with growth hormone deficiency, also is identical to human growth hormone. The current method of detecting growth hormone, analyzing levels of insulin-like growth factor (IGF-1), isn't always accurate, the researchers said, as it is age and gender sensitive.

"If you have an 18-year-old Olympic athlete and a 38-year-old athlete, the IGF-1 values may look very different," said Kopchick, whose research is funded by the Ohio Eminent Scholars program and Ohio University's Edison Biotechnology Institute.

Because identification of rhGH misuse or abuse has high stakes -- it can make or break an athletic career -- the current method has too many variables to depend on, he said.

It's still early to tell whether these protein markers have the same age limitations, as the mice in the study live to only 2 years. But the markers may have longer half lives of several days, which would offer a wider testing window, he said.

Kopchick already is exploring how to detect rhGH in human blood and tissues through a project with Danish scientist J.O. Jorgensen. The team received a three-year grant from the World Anti-Doping Agency to look for protein markers in blood and tissues of human subjects exposed to rhGH or exercise, as well as patients with growth hormone disorders.

.


Story Source:

The above story is based on materials provided by Ohio University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio University. "Potential Protein Biomarkers For Growth Hormone Identified." ScienceDaily. ScienceDaily, 23 June 2008. <www.sciencedaily.com/releases/2008/06/080617113747.htm>.
Ohio University. (2008, June 23). Potential Protein Biomarkers For Growth Hormone Identified. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/06/080617113747.htm
Ohio University. "Potential Protein Biomarkers For Growth Hormone Identified." ScienceDaily. www.sciencedaily.com/releases/2008/06/080617113747.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins