Featured Research

from universities, journals, and other organizations

Predicting The Risk Of A Common Fungal Infection After Stem Cell Transplantation

Date:
June 19, 2008
Source:
Public Library of Science
Summary:
In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients. Investigators have found that genetic variation within the plasminogen gene in mice and men affects susceptibility to a severe and life-threatening fungal infection.

In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients.I nvestigators from Duke University Medical Center, the National Institute of Environmental Health Sciences, Roche Palo Alto, the Fred Hutchinson Cancer Research Center, and the National Jewish Medical and Research Center have found that genetic variation within the plasminogen gene in mice and men affects susceptibility to a severe and life-threatening fungal infection.

Invasive infection with Aspergillus fumigatus is a common and life-threatening infection among severely immunocompromised individuals. Despite aggressive surveillance and prophylaxis, its incidence in hematopoietic stem cell transplant recipients hovers around 10%, and the three-month mortality rate is approaching 30%.

Lead investigators Aimee Zaas and David Schwartz examined the susceptibility of different inbred mouse strains for developing invasive aspergillosis after receiving immunosuppressive therapy. The inbred strains exhibited significant and reproducible differences in survival after inhalational exposure to the fungus.

Co-author Gary Peltz and colleagues recently developed an in silico method for genetic analysis in mice that was used to analyze this survival data, which led to the rapid identification of genetic variation within the plasminogen gene as a potential susceptibility factor. Therefore, it is possible that polymorphisms in human plasminogen may also affect susceptibility. Analysis of a cohort of bone marrow transplant recipients indicated that a human plasminogen allele also affects the risk of contracting this disease.

Peltz, who is now at Stanford University, stated: "This is the first study that used a multi-species genetic mapping approach to identify genetic susceptibility factors for a severe infection."

Identification of a genetic polymorphism that influences infection after transplantation has important implications for pre and post transplant care, and possibly for the management of other immune-compromised patients. Genetic testing could identify high-risk individuals who may benefit from the use of broad-spectrum antifungal agents or enhanced monitoring for infection. It is important to emphasize, however, that further research and evaluation is required before clinical applications can be developed.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zaas AK, Liao G, Chien JW, Weinberg C, Shore D, et al. Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis. PLoS Genet, 4(6): e1000101 DOI: 10.1371/journal.pgen.1000101

Cite This Page:

Public Library of Science. "Predicting The Risk Of A Common Fungal Infection After Stem Cell Transplantation." ScienceDaily. ScienceDaily, 19 June 2008. <www.sciencedaily.com/releases/2008/06/080619203251.htm>.
Public Library of Science. (2008, June 19). Predicting The Risk Of A Common Fungal Infection After Stem Cell Transplantation. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/06/080619203251.htm
Public Library of Science. "Predicting The Risk Of A Common Fungal Infection After Stem Cell Transplantation." ScienceDaily. www.sciencedaily.com/releases/2008/06/080619203251.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins