Featured Research

from universities, journals, and other organizations

Identification Of A Tumor Suppressor Gene Associated With Patient Outcome In Neuroblastoma

Date:
June 27, 2008
Source:
Journal of the National Cancer Institute
Summary:
Expression of the CHD5 gene is frequently down-regulated in neuroblastomas, and patients whose tumors lacked CHD5 expression were more likely to have shorter event-free and overall survival compared with patients whose tumors expressed CHD5, according to a study in the June 24 issue of the Journal of the National Cancer Institute.

Expression of the CHD5 gene is frequently down-regulated in neuroblastomas, and patients whose tumors lacked CHD5 expression were more likely to have shorter event-free and overall survival compared with patients whose tumors expressed CHD5, according to a study in the June 24 issue of the Journal of the National Cancer Institute.

Neuroblastoma tumors often lack one copy of a region on the short arm of chromosome 1, called 1p36.31. Garrett Brodeur, M.D., of the Children's Hospital of Philadelphia and colleagues previously identified the smallest region spanned by the deletion in more than 1,200 patient tumors and found that 23 genes were located within the region.

In the current study, Brodeur and colleagues examined the expression pattern of CHD5 in neuroblastoma cell lines and the impact of replacing the missing copy of this gene in animal models. They also looked at the association between expression of each of the 23 genes from the region and clinical outcome in 99 patients.

Although the remaining copy of the CHD5 gene is rarely mutated in neuroblastomas, the authors found that the gene is epigenetically silenced in neuroblastoma cell lines with 1p deletion. Patients whose tumors showed high expression of CHD5 protein had approximately 7-fold longer event-free and overall survival than those patients whose tumor showed low CHD5 expression. Other genes in the region did not show a consistent association with neuroblastoma prognostic features and patient outcomes.

"These results demonstrate that CHD5 expression is strongly associated with outcome in neuroblastomas, CHD5 is the likely target of 1p deletions in these tumors, and it may have a direct role in the biology and behavior of neuroblastomas," the authors write.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fujita et al. CHD5, a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas. JNCI Journal of the National Cancer Institute, 2008; DOI: 10.1093/jnci/djn176

Cite This Page:

Journal of the National Cancer Institute. "Identification Of A Tumor Suppressor Gene Associated With Patient Outcome In Neuroblastoma." ScienceDaily. ScienceDaily, 27 June 2008. <www.sciencedaily.com/releases/2008/06/080625112032.htm>.
Journal of the National Cancer Institute. (2008, June 27). Identification Of A Tumor Suppressor Gene Associated With Patient Outcome In Neuroblastoma. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/06/080625112032.htm
Journal of the National Cancer Institute. "Identification Of A Tumor Suppressor Gene Associated With Patient Outcome In Neuroblastoma." ScienceDaily. www.sciencedaily.com/releases/2008/06/080625112032.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins