Featured Research

from universities, journals, and other organizations

Footrot Vaccine For Sheep Closer Than Ever

Date:
July 2, 2008
Source:
Monash University
Summary:
Scientists have started clinical trials to find a successful vaccine against footrot in sheep.

Monash University scientists have started clinical trials to find a successful vaccine against footrot in sheep. Footrot is a highly contagious disease that attacks the feet of sheep causing severe lameness and loss of body condition. It is prevalent in many countries around the world and, in Australia, the financial impact of the disease on the wool and livestock industry is estimated at $100 million a year.

The trials over three years are taking place at Monash University's Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics and the University of Sydney.

"The trials are the culmination of 8 years of collaborative work on the pathogenic bacterium which causes footrot, Dichelobacter nodosus. We have determined the bacterium's complete DNA sequence, which was then analysed to identify proteins that are potentially exposed on the surface of the causative bacterium and therefore more likely to elicit an immune response," Chief investigator Professor Julian Rood said.

"The approach, called reverse vaccinology, identified 90 proteins in the footrot bacterium that are potential antigens for a new cross-protective vaccine. This funding will allow us to pinpoint those proteins that will target the disease in a vaccine application," Professor Rood said.

"Our Centre's approach has made significant inroads in the development of a novel vaccine for footrot. The trialling process involves treating sheep with purified surface expressed proteins to assess whether they produce an immune response. The AWI funding means the development of a marketable vaccine is likely to happen a lot sooner. Ideally, this could be within a decade."

The trials have been made possible with funding of $663,000 from Australian Wool Innovation (AWI). Australian Wool Innovation's Program Manager of Animal Health, Productivity and Welfare, Dr Johann Schröder said footrot has long been the bane of Australian woolgrowers and prime lamb producers.

"While many improvements have been made over the years in its control, and we have a very good understanding of measures to limit its impact on production, this avenue of research holds great promise," Dr Schröder said.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Cite This Page:

Monash University. "Footrot Vaccine For Sheep Closer Than Ever." ScienceDaily. ScienceDaily, 2 July 2008. <www.sciencedaily.com/releases/2008/07/080702080619.htm>.
Monash University. (2008, July 2). Footrot Vaccine For Sheep Closer Than Ever. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2008/07/080702080619.htm
Monash University. "Footrot Vaccine For Sheep Closer Than Ever." ScienceDaily. www.sciencedaily.com/releases/2008/07/080702080619.htm (accessed August 21, 2014).

Share This




More Plants & Animals News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) — According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com
California Drought Stings Honeybees, Beekeepers

California Drought Stings Honeybees, Beekeepers

AP (Aug. 21, 2014) — California's record drought is hurting honey supplies and raising prices for consumers. The lack of rainfall means fewer crops and wildflowers that provide the nectar bees need to make honey. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins