Featured Research

from universities, journals, and other organizations

Healthy Or Diseased? Analysis Of Body's Metabolism Sheds New Light On The Question

Date:
July 5, 2008
Source:
Helmholtz Zentrum München - German Research Center for Environmental Health
Summary:
Scientists have shown that biological indicators for diseases caused or influenced by environmental factors can be detected by the systemic analysis of the body's metabolism (metabolomics). The procedure presented here is also suitable for pre-clinical drug testing and allows for the early detection of possible side effects of a new medication.

Scientists from the Institute for Bioinformatics and Systemic Biology of the Helmholtz Zentrum München and the Faculty for Biology of the Ludwig-Maximilians-Universität have shown that biological indicators for diseases caused or influenced by environmental factors can be detected by the systemic analysis of the body’s metabolism (metabolomics).

Related Articles


The procedure presented here is also suitable for pre-clinical drug testing and allows for the early detection of possible side effects of a new medication.

Metabolomics aims to determine the totality of all small molecules of a cell or a tissue. The exponents of bioinformatics analyzed data collected in the framework of a pre-clinical metabolomics study in healthy and diabetic mice. In each case, a subgroup of the animals was treated with the diabetes drug RoziglitazoneTM. Then, more than 800 metabolites were quantitatively determined in a blood plasma sample of a total of forty mice, representing the factors "healthy/diabetic" and "treated/untreated".

Karsten Suhre, who led the work at the Helmholtz Zentrum München, explains the results: "It transpired that in many cases the ratios between the concentrations of certain metabolites were much more informative than their absolute concentrations." By a subsequent clustering of the test statistics of such metabolite pairs, it is possible to identify groups of metabolites which discriminate the animals by the factors "healthy/diabetic" or "treated/untreated".

The present results show that diabetes-biomarkers can be identified by means of an objective bioinformatics analysis of complex metabolomics data obtained in high-throughput experiments. Suhre added: "This bioinformatics approach can be used, in conjunction with the new metabolomics technology platform (metaP) at the Helmholtz Zentrum München, for the automatic identification of groups of relevant biomarkers of disease. Additionally, with the pre-clinical investigation of the effect of new drugs, metabolomics permits for the early identification of possible side effects on the metabolism.

Hitherto, genetic methods and/or transcription analyses stood rather to the fore in the investigation of metabolic diseases. Now, advances in the area of mass spectroscopy allow for the extensive examination of the metabolome. "With this recent quantum leap in the area of metabolite analysis, the challenge to bioinformatics is to develop customized, numerical evaluation methods to handle the complexity of these high quantity metabolomic data sets", explains Karsten Suhre.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum München - German Research Center for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Altmaier et al. Bioinformatics Analysis of Targeted Metabolomics%u2014Uncovering Old and New Tales of Diabetic Mice under Medication. Endocrinology, (2008) 149(7): 3478-3489 DOI: 10.1210/en.2007-1747

Cite This Page:

Helmholtz Zentrum München - German Research Center for Environmental Health. "Healthy Or Diseased? Analysis Of Body's Metabolism Sheds New Light On The Question." ScienceDaily. ScienceDaily, 5 July 2008. <www.sciencedaily.com/releases/2008/07/080702094554.htm>.
Helmholtz Zentrum München - German Research Center for Environmental Health. (2008, July 5). Healthy Or Diseased? Analysis Of Body's Metabolism Sheds New Light On The Question. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2008/07/080702094554.htm
Helmholtz Zentrum München - German Research Center for Environmental Health. "Healthy Or Diseased? Analysis Of Body's Metabolism Sheds New Light On The Question." ScienceDaily. www.sciencedaily.com/releases/2008/07/080702094554.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins