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Bone Marrow Alternative: Stem Cells From Umbilical Cord May Be Used To Treat Hepatic Diseases

Date:
July 5, 2008
Source:
Universidad de Granada
Summary:
Researchers from the Universities of Granada and León have shown that mononuclear blood cells from human umbilical cord can be an effective alternative to bone marrow. This work, to be published in the journal Cell Transplantation, could potentially mean a great advance in regenerative hepatic medicine.

Scientists from the University of Granada (Spain), in collaboration with the University of León, have confirmed that stem cells from human umbilical cord blood can be an appropriate therapy for the treatment of hepatic diseases such as hepatitis, and are therefore an effective alternative to bone marrow.

According to a scientific paper to be published in the journal Cell Transplantation, human umbilical cord blood cells (HUCBCs) are useful for hepatic regenerative medicine, as they are capable of nesting in the liver after carrying out a xenotransplant from human to rat.

This work, carried out by Ana I. Álvarez-Mercado, María J. Sáez-Lara, María V. García-Mediavilla, Sonia Sánchez-Campos, Francisco Abadía, María Cabello-Donayre, Ángel Gil, Javier González-Gallego and Luis Fontana, did research into the regenerative potential of HUCBCs cells using a xenotransplant model from human to rat in which HUCBCs were injected through the hepatic portal vein of rats with hepatitis caused by D-galactosamine.

Significant improvements

The scientists explain that the cell transplant carried out in rats caused an improvement both in the histological damage and in the hepatic function, as proved by the enzymatic activities of alanine transaminase, alkaline phosphatase, gama-glutamyl-transpherase and lactate dehydrogenase, as well as the concentrations of total and direct bilirubin.

The present treatment for terminal hepatic failure consists of a liver transplant. This method is, however, limited due to the lack of donor organs. In addition, there is not at present a specific treatment for the fibrosis caused by many hepatic diseases, so that receive a treatment for the complications of the disease. The development of such alternatives is therefore an essential objective for present research to improve suffering in many patients.


Story Source:

The above story is based on materials provided by Universidad de Granada. Note: Materials may be edited for content and length.


Cite This Page:

Universidad de Granada. "Bone Marrow Alternative: Stem Cells From Umbilical Cord May Be Used To Treat Hepatic Diseases." ScienceDaily. ScienceDaily, 5 July 2008. <www.sciencedaily.com/releases/2008/07/080703115403.htm>.
Universidad de Granada. (2008, July 5). Bone Marrow Alternative: Stem Cells From Umbilical Cord May Be Used To Treat Hepatic Diseases. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/07/080703115403.htm
Universidad de Granada. "Bone Marrow Alternative: Stem Cells From Umbilical Cord May Be Used To Treat Hepatic Diseases." ScienceDaily. www.sciencedaily.com/releases/2008/07/080703115403.htm (accessed July 24, 2014).

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