Featured Research

from universities, journals, and other organizations

New Therapeutic Options For Diabetes-related Tissue Injury

Date:
July 4, 2008
Source:
International & American Association for Dental Research
Summary:
Diabetes mellitus is a metabolic disorder characterized by altered glucose tolerance and impaired lipid and carbohydrate metabolism, and is associated with a number of complications directly resulting from hyperglycemiainduced inflammation.

Diabetes mellitus is a metabolic disorder characterized by altered glucose tolerance and impaired lipid and carbohydrate metabolism, and is associated with a number of complications directly resulting from hyperglycemiainduced inflammation.

Vascular changes in diabetes lead to increased risk of myocardial infarction and stroke due to atherosclerosis, retinopathy, end-stage renal disease, debilitating neuropathies, poor wound healing, enhanced risk of infection, and periodontal disease.

Studies of diabetic complications suggest that activation of the inflammatory response is mediated in large part by phagocytic cells, macrophages, and polymorphonuclear leukocytes. Both cell types assume an aggressive proinflammatory phenotype resulting from hyperglycemia.

Today, during the 86th General Session of the International Association for Dental Research, investigators from Boston University report results from a study demonstrating that omega-6 and omega-3 fatty acids are precursors to a powerful new genus of anti-inflammatory and pro-resolution mediators, coined 'resolvins' and 'protectins'.

These new local mediators counter-regulate pro-inflammatory signals and return tissues to homeostasis. These mediators reverse several of the proinflammatory functional responses of polymorphonuclear leukocytes and macrophages in vitro and prevent inflammation in a variety of animal models, and exhibit potential for new therapeutic options for resolving inflammation and tissue injury in diabetes.

This research is supported by USPHS Grants DE15566 and RR00533.

This is a summary of an abstract entitled "Resolvin-E1 and Lipoxin-A4 Control Pro-inflammatory PMN Functions in Diabetes", by A. Blackwood et al., of Boston University and Harvard University Medical School, to be presented on Friday, July 4, 2008, in Hall D-E of the Metro Toronto Convention Centre, Toronto, ON, Canada, during the 86th General Session of the International Association for Dental Research.


Story Source:

The above story is based on materials provided by International & American Association for Dental Research. Note: Materials may be edited for content and length.


Cite This Page:

International & American Association for Dental Research. "New Therapeutic Options For Diabetes-related Tissue Injury." ScienceDaily. ScienceDaily, 4 July 2008. <www.sciencedaily.com/releases/2008/07/080704130802.htm>.
International & American Association for Dental Research. (2008, July 4). New Therapeutic Options For Diabetes-related Tissue Injury. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2008/07/080704130802.htm
International & American Association for Dental Research. "New Therapeutic Options For Diabetes-related Tissue Injury." ScienceDaily. www.sciencedaily.com/releases/2008/07/080704130802.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins