Featured Research

from universities, journals, and other organizations

Cancer Therapies From The Ocean?

Date:
July 7, 2008
Source:
Society for Experimental Biology
Summary:
Scientists have studied the properties of natural products derived from animals found in Fijian waters, and shown that not only may certain compounds have potential use in anti-cancer therapies, but others may also be useful for improving drug delivery, currently one of the most significant problems faced by medical researchers.

Scientists from Aberdeen, Luxembourg and the South Pacific have studied the properties of natural products derived from animals found in Fijian waters, and shown that not only may certain compounds have potential use in anti-cancer therapies, but others may also be useful for improving drug delivery, currently one of the most significant problems faced by medical researchers.

Related Articles


Professor Marcel Jaspars from the University of Aberdeen will present insights into these new compounds on Monday 7th July at the Society for Experimental Biology's Annual Meeting in Marseille.

The team has focused on finding compounds which interfere with a protein termed NF-kB. This particular protein is known to have a critical role in many types of cancer, as well as a number of other diseases including inflammatory bowel disease, arthritis and asthma, so there is a major drive to find molecules which can inhibit its activity. "We have tested a large number of marine species to see which can prevent NF-kB from working," explains Professor Jaspars.

Professor Jaspars continues, "A few animals, including sponges, soft corals and sea lilies, were examined further, and from these we have been able to isolate and characterise the compounds responsible. We have shown that one of these molecules is able to allow normal cell death (which NK-kB switches off in some cancerous cells) to start up again, a property which we will be going onto study in much more detail."

There is another possible application of molecules isolated from marine creatures that has the potential to have just as great an impact on the development of new medicines: "It is an unfortunate reality that currently, many new excellent drugs are discovered that cannot be delivered effectively to the places where they are required," Professor Jaspars reveals.

"However, we have isolated one compound from a Mediterranean sponge that may help to end this trend. This molecule can reversibly create pores in cell membranes, a property for we envisage vast possibilities in the transportation of medicinal drugs. As we can now make this compound in the lab in large quantities, we are now able to investigate possible applications of the molecule, including drug delivery into tumours, gene delivery for cystic fibrosis and delivery of drugs into the eye."

Background Information:

NF-kB (nuclear factor-kappa B) is a protein complex that is a can control gene expression. It is involved in immune responses to infection and has been shown to play a role in many diseases including cancer, inflammatory and autoimmune diseases.


Story Source:

The above story is based on materials provided by Society for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Society for Experimental Biology. "Cancer Therapies From The Ocean?." ScienceDaily. ScienceDaily, 7 July 2008. <www.sciencedaily.com/releases/2008/07/080707093408.htm>.
Society for Experimental Biology. (2008, July 7). Cancer Therapies From The Ocean?. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2008/07/080707093408.htm
Society for Experimental Biology. "Cancer Therapies From The Ocean?." ScienceDaily. www.sciencedaily.com/releases/2008/07/080707093408.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins