Featured Research

from universities, journals, and other organizations

Giving An Additional Early Vaccination May Reduce Measles Outbreaks

Date:
July 27, 2008
Source:
BMJ-British Medical Journal
Summary:
Outbreaks of measles in developing countries may be reduced by vaccinating infants at 4.5 months of age as well as at the World Health Organization's recommended routine vaccination at 9 months, according to a new study.

Outbreaks of measles in developing countries may be reduced by vaccinating infants at 4.5 months of age as well as at the World Health Organization's recommended routine vaccination at 9 months, according to a study published on the British Medical Journal website.

These findings should lead to reconsideration of the policy for vaccination during measles outbreaks and in humanitarian emergencies, say the authors.

Maternal antibodies protect against measles during the first months of life and infants routinely receive their first vaccination between 9 and 15 months to coincide with when these maternal antibodies are lost. This vaccination policy was based on children born to naturally infected mothers, but measles vaccination campaigns over the past 20-25 years in low income countries have resulted in many mothers being immunised and transferring only half the maternal measles antibodies as naturally immune mothers.

Similarly, HIV positive mothers transfer a smaller number of antibodies than HIV negative mothers and HIV positive children also lose their protective maternal antibodies early. As a result, a new group of children now exist who may lose their protection by 3 to 5 months of age and there may well be a need to provide measles vaccination at an earlier age.

A measles outbreak in Guinea-Bissau in Africa offered Professor Peter Aaby and colleagues a unique opportunity to assess the protective effect of earlier vaccination at 4.5 months. 1333 infants were randomised to receive either measles vaccination at 4.5 months of age (441) or nothing (892). At 9 months of age all children received a measles vaccination. Blood samples were collected to assess levels of maternal antibodies levels against measles at 4.5, 9, and 24 months of age in the early vaccination group and at 9, 18, and 24 months of age in the control group.

The researchers found that early vaccination at 4.5 months of age offered more than 90% protection against measles infection and 100% protection against measles hospitalisation.

Prior to the initial vaccination at 4.5 months of age only 28% of the children had protective levels of maternal antibodies against measles. After this early vaccination 92% had measles antibodies at 9 months of age.

The researchers found that children vaccinated at 4.5 months and 9 months were better protected than those vaccinated only at 9 months. The monthly incidence of measles was 0.7% in the children who received two doses and 3.1% in the children who received one dose at 9 months.

"If elimination of measles is planned it will be necessary in Africa to immunise as early as possible for many years", conclude the authors.

These findings offer policymakers potential alternative vaccination strategies, but research is required to determine the possible immunosuppressive effect from live virus measles vaccines on other vaccine responses when given in early infancy, say Dr Hιlθne Broutin and Dr Mark A Miller from the National Institutes of Health, in an accompanying editorial.

"The current goal to achieve high vaccine coverage should not be separated from the need for more timely vaccination, especially in developing countries…[but] earlier measles vaccination should not substitute for the dose given to infants at ages 9-15 months, which increases overall immunity in the population", they conclude.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Giving An Additional Early Vaccination May Reduce Measles Outbreaks." ScienceDaily. ScienceDaily, 27 July 2008. <www.sciencedaily.com/releases/2008/07/080724212907.htm>.
BMJ-British Medical Journal. (2008, July 27). Giving An Additional Early Vaccination May Reduce Measles Outbreaks. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/07/080724212907.htm
BMJ-British Medical Journal. "Giving An Additional Early Vaccination May Reduce Measles Outbreaks." ScienceDaily. www.sciencedaily.com/releases/2008/07/080724212907.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins