Featured Research

from universities, journals, and other organizations

Giving An Additional Early Vaccination May Reduce Measles Outbreaks

Date:
July 27, 2008
Source:
BMJ-British Medical Journal
Summary:
Outbreaks of measles in developing countries may be reduced by vaccinating infants at 4.5 months of age as well as at the World Health Organization's recommended routine vaccination at 9 months, according to a new study.

Outbreaks of measles in developing countries may be reduced by vaccinating infants at 4.5 months of age as well as at the World Health Organization's recommended routine vaccination at 9 months, according to a study published on the British Medical Journal website.

These findings should lead to reconsideration of the policy for vaccination during measles outbreaks and in humanitarian emergencies, say the authors.

Maternal antibodies protect against measles during the first months of life and infants routinely receive their first vaccination between 9 and 15 months to coincide with when these maternal antibodies are lost. This vaccination policy was based on children born to naturally infected mothers, but measles vaccination campaigns over the past 20-25 years in low income countries have resulted in many mothers being immunised and transferring only half the maternal measles antibodies as naturally immune mothers.

Similarly, HIV positive mothers transfer a smaller number of antibodies than HIV negative mothers and HIV positive children also lose their protective maternal antibodies early. As a result, a new group of children now exist who may lose their protection by 3 to 5 months of age and there may well be a need to provide measles vaccination at an earlier age.

A measles outbreak in Guinea-Bissau in Africa offered Professor Peter Aaby and colleagues a unique opportunity to assess the protective effect of earlier vaccination at 4.5 months. 1333 infants were randomised to receive either measles vaccination at 4.5 months of age (441) or nothing (892). At 9 months of age all children received a measles vaccination. Blood samples were collected to assess levels of maternal antibodies levels against measles at 4.5, 9, and 24 months of age in the early vaccination group and at 9, 18, and 24 months of age in the control group.

The researchers found that early vaccination at 4.5 months of age offered more than 90% protection against measles infection and 100% protection against measles hospitalisation.

Prior to the initial vaccination at 4.5 months of age only 28% of the children had protective levels of maternal antibodies against measles. After this early vaccination 92% had measles antibodies at 9 months of age.

The researchers found that children vaccinated at 4.5 months and 9 months were better protected than those vaccinated only at 9 months. The monthly incidence of measles was 0.7% in the children who received two doses and 3.1% in the children who received one dose at 9 months.

"If elimination of measles is planned it will be necessary in Africa to immunise as early as possible for many years", conclude the authors.

These findings offer policymakers potential alternative vaccination strategies, but research is required to determine the possible immunosuppressive effect from live virus measles vaccines on other vaccine responses when given in early infancy, say Dr Hιlθne Broutin and Dr Mark A Miller from the National Institutes of Health, in an accompanying editorial.

"The current goal to achieve high vaccine coverage should not be separated from the need for more timely vaccination, especially in developing countries…[but] earlier measles vaccination should not substitute for the dose given to infants at ages 9-15 months, which increases overall immunity in the population", they conclude.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Giving An Additional Early Vaccination May Reduce Measles Outbreaks." ScienceDaily. ScienceDaily, 27 July 2008. <www.sciencedaily.com/releases/2008/07/080724212907.htm>.
BMJ-British Medical Journal. (2008, July 27). Giving An Additional Early Vaccination May Reduce Measles Outbreaks. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2008/07/080724212907.htm
BMJ-British Medical Journal. "Giving An Additional Early Vaccination May Reduce Measles Outbreaks." ScienceDaily. www.sciencedaily.com/releases/2008/07/080724212907.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins