Featured Research

from universities, journals, and other organizations

Mitochondrial DNA Copy Number Associated With Risk Of Kidney Cancer

Date:
August 1, 2008
Source:
Journal of the National Cancer Institute
Summary:
Genetic factors were shown to influence the number of copies of mitochondrial DNA (mtDNA) in healthy cells. A lower mtDNA copy number was associated with an increased risk of renal cell cancer in a case-control study.

Genetic factors were shown to influence the number of copies of mitochondrial DNA (mtDNA) in healthy cells. A lower mtDNA copy number was associated with an increased risk of renal cell cancer in a case-control study, researchers report in the July 29 online issue of the Journal of the National Cancer Institute.

The degree to which mtDNA copy number is controlled genetically has been unknown. Previous studies have suggested that low mtDNA copy number may be associated with an increased risk of a variety of cancers, but researchers have not explored its possible association with kidney cancer.

In the first portion of the study, Xifeng Wu, M.D., Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston and colleagues analyzed mtDNA copy number from the peripheral blood cells of more than 300 identical and non-identical twins to estimate the influence of genetics on copy number. In the second portion of the study, the researchers analyzed mtDNA copy number from 260 renal cell cancer patients and 281 control subjects to examine the association between copy number and renal cancer risk.

The investigators estimate that genetics accounts for 65 percent of the variation in mtDNA copy number in the population. On average, renal cancer patients had a lower mtDNA copy number in peripheral blood cells than did control subjects. They also observed a statistically significant trend for increased risk of renal cell cancer with decreasing mtDNA copy number.

"To the best of our knowledge, this is the first molecular epidemiological study to evaluate mtDNA content in lymphocytes as a susceptibility biomarker for cancer," the authors write.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Mitochondrial DNA Copy Number Associated With Risk Of Kidney Cancer." ScienceDaily. ScienceDaily, 1 August 2008. <www.sciencedaily.com/releases/2008/07/080729235441.htm>.
Journal of the National Cancer Institute. (2008, August 1). Mitochondrial DNA Copy Number Associated With Risk Of Kidney Cancer. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2008/07/080729235441.htm
Journal of the National Cancer Institute. "Mitochondrial DNA Copy Number Associated With Risk Of Kidney Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/07/080729235441.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins