Featured Research

from universities, journals, and other organizations

Human Obesity Genes Revealed Based On Fly Experiments

Date:
August 11, 2008
Source:
BioMed Central
Summary:
A study of 228 women has revealed genetic variants responsible for body shape. Based on work in the fruit fly Drosophila melanogaster, new research identifies natural variation in the human LAMA5 gene as a key determinant of weight.

A study of 228 women has revealed genetic variants responsible for body shape. Based on work in the fruit fly Drosophila melanogaster, research published in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight.

As the prevalence of obesity and related health problems continues to increase worldwide, there is considerable effort being devoted to identify genetic mechanisms that control fat storage. Maria De Luca led a team from the University of Alabama at Birmingham, USA, who identified candidate genes using different strains of Drosophila.

On the basis of the results of these fly experiments, the research team then tested three common variations in the human LAMA5 gene and discovered two gene variants that were associated with body shape, one in women of European American descent and the other affecting women of American African descent. As De Luca reports, "We found one variant to be associated with weight and lean mass in both ethnic groups. This variant was also associated with height, total fat mass and HDL-cholesterol, but only in European American women. A different variant was associated with triglyceride levels and HDL-cholesterol in African American women."

The use of flies in a study of human obesity may seem strange, but according to De Luca "Insects store fat like mammals do, as lipid droplets accumulated in the fat body, the functional equivalent of both mammalian liver and white adipose tissue". She adds that, "Drosophila share many components of fat biosynthesis, degradation and regulation with humans, including many of those implicated in diabetes and obesity".


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maria De Luca, Michelle Chambers, Krista Casazza, Kerry H Lok, Gary R Hunter, Barbara A Gower, Josι R Fernαndez. Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans. BMC Genetics, 2008; 9 (1): 52 DOI: 10.1186/1471-2156-9-52

Cite This Page:

BioMed Central. "Human Obesity Genes Revealed Based On Fly Experiments." ScienceDaily. ScienceDaily, 11 August 2008. <www.sciencedaily.com/releases/2008/08/080810214004.htm>.
BioMed Central. (2008, August 11). Human Obesity Genes Revealed Based On Fly Experiments. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2008/08/080810214004.htm
BioMed Central. "Human Obesity Genes Revealed Based On Fly Experiments." ScienceDaily. www.sciencedaily.com/releases/2008/08/080810214004.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) — As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) — When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins