Featured Research

from universities, journals, and other organizations

Mechanism Behind Cocaine Craving Identified

Date:
August 16, 2008
Source:
Vetenskapsrådet (The Swedish Research Council)
Summary:
A possible future way to prevent relapses into drug dependence has been discovered. The target is the dopamine-producing nerve cells in the midbrain.

A possible future way to prevent relapses into drug dependence has been discovered by researchers at Linköping University and the German cancer research center DKFZ. The target is the dopamine-producing nerve cells in the midbrain.

Related Articles


Earlier research has shown that these cells become more excitable when a person takes drugs. To find out the functional meaning of this, these researchers used a mouse model for cocaine dependence. When they blocked the cells’ receptors for glutamate ­- the brain’s most important signal substance -­ the risk of relapsing into addiction vanished. The findings are being published in Neuron.

Dopamine-producing nerve cells are central to the brain’s reward system. Dependence-inducing drugs cause concentrations of dopamine to rise in the surroundings, which in turn affects other nerve cells and brings about various physical and mental reactions.

Cocaine has a very rapid impact on dopamine levels, which explains why it is one of the most addictive drugs.

“When you take cocaine, the number of glutamate receptors increases, rendering the cell more excitable. When we block this process, we prevent relapses into addiction. This is interesting clinically since that is the phase when we can get hold of patients,” says David Engblom, a neurobiologist at Linköping University and the study’s lead author.

An addict who wants to give up drugs could thus be offered a ‘vaccination’ against relapsing. But much more research remains to be done before such treatment can become a reality.


Story Source:

The above story is based on materials provided by Vetenskapsrådet (The Swedish Research Council). Note: Materials may be edited for content and length.


Cite This Page:

Vetenskapsrådet (The Swedish Research Council). "Mechanism Behind Cocaine Craving Identified." ScienceDaily. ScienceDaily, 16 August 2008. <www.sciencedaily.com/releases/2008/08/080815073522.htm>.
Vetenskapsrådet (The Swedish Research Council). (2008, August 16). Mechanism Behind Cocaine Craving Identified. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/08/080815073522.htm
Vetenskapsrådet (The Swedish Research Council). "Mechanism Behind Cocaine Craving Identified." ScienceDaily. www.sciencedaily.com/releases/2008/08/080815073522.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins