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Mechanism Behind Cocaine Craving Identified

Date:
August 16, 2008
Source:
Vetenskapsrådet (The Swedish Research Council)
Summary:
A possible future way to prevent relapses into drug dependence has been discovered. The target is the dopamine-producing nerve cells in the midbrain.
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A possible future way to prevent relapses into drug dependence has been discovered by researchers at Linköping University and the German cancer research center DKFZ. The target is the dopamine-producing nerve cells in the midbrain.

Earlier research has shown that these cells become more excitable when a person takes drugs. To find out the functional meaning of this, these researchers used a mouse model for cocaine dependence. When they blocked the cells’ receptors for glutamate ­- the brain’s most important signal substance -­ the risk of relapsing into addiction vanished. The findings are being published in Neuron.

Dopamine-producing nerve cells are central to the brain’s reward system. Dependence-inducing drugs cause concentrations of dopamine to rise in the surroundings, which in turn affects other nerve cells and brings about various physical and mental reactions.

Cocaine has a very rapid impact on dopamine levels, which explains why it is one of the most addictive drugs.

“When you take cocaine, the number of glutamate receptors increases, rendering the cell more excitable. When we block this process, we prevent relapses into addiction. This is interesting clinically since that is the phase when we can get hold of patients,” says David Engblom, a neurobiologist at Linköping University and the study’s lead author.

An addict who wants to give up drugs could thus be offered a ‘vaccination’ against relapsing. But much more research remains to be done before such treatment can become a reality.


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The above post is reprinted from materials provided by Vetenskapsrådet (The Swedish Research Council). Note: Materials may be edited for content and length.


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Vetenskapsrådet (The Swedish Research Council). "Mechanism Behind Cocaine Craving Identified." ScienceDaily. ScienceDaily, 16 August 2008. <www.sciencedaily.com/releases/2008/08/080815073522.htm>.
Vetenskapsrådet (The Swedish Research Council). (2008, August 16). Mechanism Behind Cocaine Craving Identified. ScienceDaily. Retrieved August 2, 2015 from www.sciencedaily.com/releases/2008/08/080815073522.htm
Vetenskapsrådet (The Swedish Research Council). "Mechanism Behind Cocaine Craving Identified." ScienceDaily. www.sciencedaily.com/releases/2008/08/080815073522.htm (accessed August 2, 2015).

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