Featured Research

from universities, journals, and other organizations

Mechanism Behind Cocaine Craving Identified

Date:
August 16, 2008
Source:
Vetenskapsrådet (The Swedish Research Council)
Summary:
A possible future way to prevent relapses into drug dependence has been discovered. The target is the dopamine-producing nerve cells in the midbrain.

A possible future way to prevent relapses into drug dependence has been discovered by researchers at Linköping University and the German cancer research center DKFZ. The target is the dopamine-producing nerve cells in the midbrain.

Related Articles


Earlier research has shown that these cells become more excitable when a person takes drugs. To find out the functional meaning of this, these researchers used a mouse model for cocaine dependence. When they blocked the cells’ receptors for glutamate ­- the brain’s most important signal substance -­ the risk of relapsing into addiction vanished. The findings are being published in Neuron.

Dopamine-producing nerve cells are central to the brain’s reward system. Dependence-inducing drugs cause concentrations of dopamine to rise in the surroundings, which in turn affects other nerve cells and brings about various physical and mental reactions.

Cocaine has a very rapid impact on dopamine levels, which explains why it is one of the most addictive drugs.

“When you take cocaine, the number of glutamate receptors increases, rendering the cell more excitable. When we block this process, we prevent relapses into addiction. This is interesting clinically since that is the phase when we can get hold of patients,” says David Engblom, a neurobiologist at Linköping University and the study’s lead author.

An addict who wants to give up drugs could thus be offered a ‘vaccination’ against relapsing. But much more research remains to be done before such treatment can become a reality.


Story Source:

The above story is based on materials provided by Vetenskapsrådet (The Swedish Research Council). Note: Materials may be edited for content and length.


Cite This Page:

Vetenskapsrådet (The Swedish Research Council). "Mechanism Behind Cocaine Craving Identified." ScienceDaily. ScienceDaily, 16 August 2008. <www.sciencedaily.com/releases/2008/08/080815073522.htm>.
Vetenskapsrådet (The Swedish Research Council). (2008, August 16). Mechanism Behind Cocaine Craving Identified. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2008/08/080815073522.htm
Vetenskapsrådet (The Swedish Research Council). "Mechanism Behind Cocaine Craving Identified." ScienceDaily. www.sciencedaily.com/releases/2008/08/080815073522.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) — Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) — Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) — As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins