Featured Research

from universities, journals, and other organizations

Potatoes May Hold Key To Alzheimer's Treatment

Date:
August 16, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
A virus that commonly infects potatoes bears a striking resemblance to one of the key proteins implicated in Alzheimer's disease, and researchers have used that to develop antibodies that may slow or prevent the onset of AD.

Necrotic ringspots on a potato tuber (cultivar Nicola) due to Potato virus Y infection.
Credit: Karine CHARLET-RAMAGE & Camille KERLAN Laurent GLAIS & Camille KERLAN INRA-ENSA, Rennes, France

A virus that commonly infects potatoes bears a striking resemblance to one of the key proteins implicated in Alzheimer's disease (AD), and researchers have used that to develop antibodies that may slow or prevent the onset of AD.

Related Articles


Studies in mice have demonstrated that vaccinations with the amyloid beta protein (believed to be a major AD contributor) to produce A antibodies can slow disease progression and improve cognitive function, possibly by promoting the destruction of amyloid plaques. Some early human trials have likewise been promising, but had to be halted due to the risk of autoimmune encephalitis.

One way to make Alzheimer's vaccinations safer would be to use a closely-related, but not human, protein as the vaccine, much like cowpox virus is used for smallpox immunizations.

In the August 15 Journal of Biological Chemistry, Robert Friedland and colleagues used this concept on an amyloid-like protein found in potato virus (PVY). They injected PVY into mice followed by monthly boosters for four months. The researchers found that the mice produced strong levels of antibodies that could attach to amyloid beta protein both in both solution and in tissue samples of Alzheimer's patients. And although the levels were lower, mice also developed A antibodies if given injections of PVY-infected potato leaf as opposed to purified PVY.

Friedland and colleagues note that potato virus is a fairly common infection that poses no risk to humans (many people have probably eaten PVY infected potatoes). While tests of PVY antibodies will ultimately determine how useful they can be, they may be a promising lead to treating this debilitating disease.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert P. Friedland, Jonathan M. Tedesco, Andrea Wilson, Craig Atwood, Mark Smith, George Perry and Michael Zagorski. Antibodies to Potato Virus Y Bind the Amyloid Beta Peptide. Journal of Biological Chemistry, August 15, 2008 [link]

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Potatoes May Hold Key To Alzheimer's Treatment." ScienceDaily. ScienceDaily, 16 August 2008. <www.sciencedaily.com/releases/2008/08/080815170629.htm>.
American Society for Biochemistry and Molecular Biology. (2008, August 16). Potatoes May Hold Key To Alzheimer's Treatment. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2008/08/080815170629.htm
American Society for Biochemistry and Molecular Biology. "Potatoes May Hold Key To Alzheimer's Treatment." ScienceDaily. www.sciencedaily.com/releases/2008/08/080815170629.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Binge-Watching TV Linked To Loneliness

Binge-Watching TV Linked To Loneliness

Newsy (Jan. 29, 2015) Researchers at University of Texas at Austin found a link between binge-watching TV shows and feelings of loneliness and depression. Video provided by Newsy
Powered by NewsLook.com
Signs You Might Be The Passive Aggressive Friend

Signs You Might Be The Passive Aggressive Friend

BuzzFeed (Jan. 28, 2015) "No, I&apos;m not mad. Why, are you mad?" Video provided by BuzzFeed
Powered by NewsLook.com
City Divided: A Look at Model Schools in the TDSB

City Divided: A Look at Model Schools in the TDSB

The Toronto Star (Jan. 27, 2015) Model schools are rethinking how they engage with the community to help enhance the lives of the students and their parents. Video provided by The Toronto Star
Powered by NewsLook.com
Man Saves Pennies For 65 Years

Man Saves Pennies For 65 Years

Rooftop Comedy (Jan. 26, 2015) A man in Texas saved every penny he found for 65 years, and this week he finally cashed them in. Bank tellers at Prosperity Bank in Slaton, Texas were shocked when Ira Keys arrived at their bank with over 500 pounds of loose pennies stored in coffee cans. After more than an hour of sorting and counting, it turned out the 81 year-old was in possession of 81,600 pennies, or $816. And he&apos;s got more at home! Video provided by Rooftop Comedy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins