Featured Research

from universities, journals, and other organizations

Deletion Of Chromatin Remodeling Genes Leads To Leukemia In Mice

Date:
August 27, 2008
Source:
Journal of the National Cancer Institute
Summary:
Mice lacking both copies of the Arid4A gene and one copy of the Arid4B gene develop acute myeloid leukemia (AML) and may provide an important animal model for preleukemic and leukemic conditions, according to an article in the Aug. 26 online issue of the Journal of the National Cancer Institute.

Mice lacking both copies of the Arid4A gene and one copy of the Arid4B gene develop acute myeloid leukemia (AML) and may provide an important animal model for preleukemic and leukemic conditions, according to an article in the Aug. 26 online issue of the Journal of the National Cancer Institute.

It is well known that genetic mutations, which alter the sequence of DNA in chromosomes, can lead to cancer. More recently, researchers have found that changes in chromatin structure and activity (epigenetic changes) can lead to cancer as well. The Arid4 family of genes is involved in chromosome remodeling, but their impact on leukemia was not known.

Arthur Beaudet, M.D., of Baylor College of Medicine in Houston and colleagues bred mice that lacked both copies of Arid4A and one copy of Arid4B. They monitored the animals' health through repeated blood cell counts and molecular tests on blood and bone marrow cells.

The mutant mice developed a myeloproliferative disorder that resembled chronic myeloid-monocytic leukemia. The animals then progressed to AML. The pattern of disease progression in the animals resembled the course of events in humans and may indicate that the mutant mice are useful models for studying how AML develops and testing potential therapeutics.

"Further study of the Arid4 gene family may advance our understanding of the connection between gene regulation, epigenetic control, disease development, and cancer formation," the authors write. "We also suggest that gene regulation by the ARID4A and ARID4B should be examined for potential disease-related roles, not only in human malignancies, but also in other complex disease traits."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mei-Yi Wu, Karen W. Eldin, and Arthur L. Beaudet. Identification of Chromatin Remodeling Genes Arid4a and Arid4b as Leukemia Suppressor Genes. Journal of the National Cancer Institute, 2008; DOI: 10.1093/jnci/djn253

Cite This Page:

Journal of the National Cancer Institute. "Deletion Of Chromatin Remodeling Genes Leads To Leukemia In Mice." ScienceDaily. ScienceDaily, 27 August 2008. <www.sciencedaily.com/releases/2008/08/080827223156.htm>.
Journal of the National Cancer Institute. (2008, August 27). Deletion Of Chromatin Remodeling Genes Leads To Leukemia In Mice. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2008/08/080827223156.htm
Journal of the National Cancer Institute. "Deletion Of Chromatin Remodeling Genes Leads To Leukemia In Mice." ScienceDaily. www.sciencedaily.com/releases/2008/08/080827223156.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins