Featured Research

from universities, journals, and other organizations

Why Transplanted Insulin Cells Die

Date:
August 28, 2008
Source:
Swedish Research Council
Summary:
New research can enhance survival of islets transplants and improve treatment of type 1 diabetes.

New research can enhance survival of islets transplants and improve treatment of type 1 diabetes.

Transplantation of insulin-producing cell islets, so-called islets of langerhans is an appealing strategy for treatment of type 1 diabetes. But it turns out that these are short-lived, and the procedure needs to be repeated.

Now researchers at Linkφping University and Uppsala University in Sweden can show that accumulation of protein aggregatess, amyloid, in the transplanted cells may be causing their death.

Until now it was not known why this insulin production ceases. The discovery now being published in The New England Journal of Medicine may change the course of diabetes research.

Transplant attempts have been carried out for more than 30 years. Hundreds of patients have had healthy insulin-producing islets of Langerhans recovered from the pancreas of donors. These transplants, which usually involve the injection of cell islets into the liver, normally go well, and the patients initially don’t have to take insulin. But within a year or two years the insulin production will cease from the transplanted cells.

“We have studied this in mice, but it has naturally been difficult to do so in humans. Now we have had an opportunity to examine such transplants in an individual with type 1 diabetes,” says Gunilla T. Westermark, assistant professor of cell biology at Linkφping University.

In close to half of the cell islets examined, 43 percent, the researchers found lumps of amyloid.

“We previously know that amyloid production is a symptom of stress that leads to cell death in type 2 diabetes. Perhaps the same thing happens in a transplant, when cells are exposed to great stress,” says Gunilla T. Westermark.

Interestingly, there were quite a few unaffected cell islets remaining in the liver. If we can prevent the production of amyloid at an early stage, these cells would be able to continue to produce insulin. One possible strategy is to create a drug; another would be to refine the methods used in transplants in order to reduce stress.


Story Source:

The above story is based on materials provided by Swedish Research Council. Note: Materials may be edited for content and length.


Journal Reference:

  1. Westermark et al. Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets. New England Journal of Medicine, 2008; 359 (9): 977 DOI: 10.1056/NEJMc0802893

Cite This Page:

Swedish Research Council. "Why Transplanted Insulin Cells Die." ScienceDaily. ScienceDaily, 28 August 2008. <www.sciencedaily.com/releases/2008/08/080828084320.htm>.
Swedish Research Council. (2008, August 28). Why Transplanted Insulin Cells Die. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/08/080828084320.htm
Swedish Research Council. "Why Transplanted Insulin Cells Die." ScienceDaily. www.sciencedaily.com/releases/2008/08/080828084320.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) — The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) — The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) — The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) — In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins