Featured Research

from universities, journals, and other organizations

Promising Method For Reducing MRSA Infections In Hospitals

Date:
September 5, 2008
Source:
University of Virginia Health System
Summary:
Researchers report that switching between two antibiotics, linezolid and vancomycin, every three months in the surgical ICU decreased the MRSA infection rate from 1.9 to 1.4 patients per 100 admissions. In-hospital mortality from surgical ICU-acquired MRSA infections fell from 3.8 patients per year to none.

Doctors at the University of Virginia Health System have significantly reduced MRSA infections among surgical intensive care patients by using antibiotic cycling, a method of rotating drugs at regular intervals.

UVA researchers report that switching between two antibiotics, linezolid and vancomycin, every three months in the surgical ICU decreased the MRSA infection rate from 1.9 to 1.4 patients per 100 admissions. In-hospital mortality from surgical ICU-acquired MRSA infections fell from 3.8 patients per year to none.

Study data spanned six years, including the period before cycling began (1997 to 2001) and the period after it was instituted (2002 to 2003). The study's key focus was resistant gram-positive cocci, a subgroup defined as MRSA (which stands for methicillin-resistant Staphylococcus aureus) and VRE (which is an acronym for vancomycin-resistant Enterococcus).

"Before we began cycling, 67 percent of the Staphylococcus aureus infections in our surgical ICU were caused by MRSA," notes the study's lead author, Dr. Robert Sawyer, a professor of surgery and co-director of UVA's Surgical Trauma Intensive Care Unit. "Cycling reduced MRSA cases to 36 percent of that total."

The UVA study is the first to assess the impact of antibiotic cycling on a group of bacteria known as gram-positive cocci. Increasingly problematic in hospitals, these pathogens tend to develop resistance to antibiotics in sterile and contained environments - areas like ICUs - where patients have weakened immune systems due to severe illness, open wounds, surgical incisions, catheters or other implanted medical devices. At UVA, surgical ICU patients include those who are recovering from trauma, organ transplants or invasive procedures.

According to Dr. Sawyer, UVA's findings are important, yet need to be confirmed by similar studies in other ICU's. "If cycling proves effective at other centers, we might be able to turn the tide on antibiotic resistance, at least for MRSA. In the long run, reducing MRSA should decrease the number of deaths among critically ill patients," he notes. "However, the problem is very complex and will almost certainly need a variety of interventions to achieve the best outcomes."

While MRSA infection rates fell during cycling, the prevalence of VRE remained virtually unaltered. VRE infection rates rose slightly, from .76 to .98 patients per 100 admissions. In-hospital mortality from VRE dropped from 2.8 to 2.5 patients per year.

Cycling reduced the surgical ICU's overall gram-positive infection rate from 19.6 to 11.8 patients per 100 admissions. It lowered the rate of infections from resistant gram-positive cocci from 4.6 to 1.7 patients per 100 admissions.


Story Source:

The above story is based on materials provided by University of Virginia Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Smith et al. Reduction in Rates of Methicillin-Resistant Staphylococcus aureus Infection after Introduction of Quarterly Linezolid–Vancomycin Cycling in a Surgical Intensive Care Unit. Surgical Infections, 2008; 9 (4): 423 DOI: 10.1089/sur.2007.024

Cite This Page:

University of Virginia Health System. "Promising Method For Reducing MRSA Infections In Hospitals." ScienceDaily. ScienceDaily, 5 September 2008. <www.sciencedaily.com/releases/2008/09/080904115117.htm>.
University of Virginia Health System. (2008, September 5). Promising Method For Reducing MRSA Infections In Hospitals. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2008/09/080904115117.htm
University of Virginia Health System. "Promising Method For Reducing MRSA Infections In Hospitals." ScienceDaily. www.sciencedaily.com/releases/2008/09/080904115117.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins