Sep. 19, 2008 Scientists of the University of Granada (Spain) and the San Cecilio Teaching Hospital (Granada) have identified genes linked to blindness produced by corneal oedema.
The research group of Tissue Engineering of the UGR and the San Cecilio University Hospital, who has recently constructed the first complete artificial cornea, has established new findings related to blindness caused by corneal oedema originated by the alteration of the cell barrier of corneal endothelium. When the endothelial cell barrier is unharmed, the cornea remains dehydrated and transparent.
An oedema is a swelling caused by the accumulation of liquid in the tissues of the human body, including cornea. The researchers of Granada have shown that the alteration of the mechanisms that regulate the volume of endothelial cells and their content in ions is the cause for which the endothelial barrier stops being effective in the control of corneal transparency.
The research work has experimentally established the volume and concentration of ions in cells when they make up the endothelial barrier and when they stop forming it. If, due to a traumatism, cataract surgery, ageing, etc., the barrier of endothelial cells breaks, dispersed cells increase their volume and content in ions, potassium and chlorine.
The goal of these changes is to repair the endothelial barrier, prevent corneal oedema and, therefore, the loss of transparency and the resulting blindness. The research carried out in the University of Granada has also determined the genes involved in the control of such process.
Such recent findings suggest new treatments for corneal oedema. The scientists explain that maybe in the not too distant future it will be possible to use eye drops which provide the ions involved or even the possibility of modifying the affected genes by means of gene therapy, which could mend or palliate some of these alterations.
The authors of the work are Professors Miguel Alaminos, Miguel González Andrades, José Ignacio Muñoz Ávila, Ingrid Garzón, Mª Carmen Sánchez Quevedo and Antonio Campos.
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- Alaminos et al. Volumetric and ionic regulation during the in vitro development of a corneal endothelial barrier. Experimental Eye Research, 2008; 86 (5): 758 DOI: 10.1016/j.exer.2008.02.003
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