Featured Research

from universities, journals, and other organizations

Healthy Blood Vessels May Prevent Fat Growth

Date:
September 23, 2008
Source:
Indiana University
Summary:
Cells lining blood vessels may perform an unsuspected task -- controlling the development of fat cells. Researchers found that precursor or stem cells have a markedly reduced tendency to develop into fat cells when placed in direct contact with healthy endothelial cells, which are the cells that line blood vessels.

The cells lining blood vessels are known to be important for maintaining health, but researchers at the Indiana University School of Medicine believe these cells may perform an unsuspected task – controlling the development of fat cells.

Related Articles


Their findings are reported in the September issue of the journal Stem Cells.

The researchers found that precursor or stem cells have a markedly reduced tendency to develop into fat cells when placed in direct contact with healthy endothelial cells, which are the cells that line blood vessels.

"The key to this discovery was our recent observation that these cells, also known as adipose stromal cells, in fat tissue are in very close contact with endothelial cells in small blood vessels and capillaries," said Keith L. March, M.D., Ph.D., co-principal investigator of the study and director of the Indiana Center for Vascular Biology and Medicine (ICVBM).

"Once we had recognized this link between endothelial and stromal cells, it was a logical step to ask how these cells can influence each other," said Dr. March, who also is a professor of medicine, physiology and biomedical engineering at the IU School of Medicine and Krannert Institute of Cardiology.

Dr. March and his colleagues are researching uses for one of nature's building blocks, adipose stem cells, which they harvest from fat tissues. Their research looks at ways to treat vascular disease, including the use of adipose stem cells to grow new vessels as a treatment for peripheral artery disease.

When the adipose stem cells were mixed with endothelial cells, they were less likely to develop into fat cells, said Gangaraju Rajashekhar, Ph.D., lead author of the journal article and a research associate at the Indiana Center for Vascular Biology and Medicine.

What we discovered was that endothelial cells released proteins – including Wnt proteins to be precise – that play a significant role in blocking fat cell development. Wnt proteins regulate development and differentiation in many tissues and may even play a role in aging," said Dr. Rajashekhar.

The researchers cautioned that more studies are needed to determine whether repair of unhealthy endothelial cells also can help to control fat growth.

"We know now that endothelial cells in blood vessels cells help tell adipose stem cells what to do," said Matthias Clauss, Ph.D., an ICVBM co-principal investigator of the study and an associate professor for cellular and integrative physiology at the IU School of Medicine.

"What we don't know yet is how the formation of fat cells influences the blood vessel lining cells. Our current hypothesis is that endothelial dysfunction promotes fat cell development, accompanied by new blood vessel growth. We hope to soon be able to interrupt this cycle," said Dr. Clauss.

This research may result in new options for treatment of cardiovascular diseases and also could provide physicians with another weapon in the war on obesity.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "Healthy Blood Vessels May Prevent Fat Growth." ScienceDaily. ScienceDaily, 23 September 2008. <www.sciencedaily.com/releases/2008/09/080922122525.htm>.
Indiana University. (2008, September 23). Healthy Blood Vessels May Prevent Fat Growth. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2008/09/080922122525.htm
Indiana University. "Healthy Blood Vessels May Prevent Fat Growth." ScienceDaily. www.sciencedaily.com/releases/2008/09/080922122525.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins