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Aspirin And Atherosclerosis: Mechanism Uncovered

Date:
September 25, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have uncovered the mechanism that may explain aspirin's ability to prevent arterial plaque buildup and atherosclerosis.

Aspirin has become one of the most widely used medications in the world, owing to its ability to reduce pain, fevers, inflammation, and blood clotting. In animal studies, aspirin has also been shown to prevent atherosclerosis, though none of its known mechanisms of action would seem to account for this.

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In a new study, though, researchers have uncovered the mechanism that may explain aspirin's ability to prevent arterial plaque buildup.

Using cell culture and mouse models, Sampath Parthasarathy and colleagues observed that aspirin –specifically its active byproduct salicylate– can greatly increase the expression of two proteins: paraoxonase 1 (PON1) and apolipoprotein A1 (ApoA1); in the mouse studies, low dose aspirin supplements could increase PON1 and ApoA1 levels by 7- and 12- fold, respectively.

Both of these proteins are beneficial components of the HDL complex, the "good cholesterol" that helps prevent atherosclerosis; ApoA1 removes bad cholesterol from the bloodstream while PON1 is an antioxidant that breaks down toxic lipid peroxides.

The researchers also noted that the heightened expression of PON1 was accompanied by an increase in a receptor called AHR (aryl hydrocarbon receptor); this was intriguing as a chemical known to attach to AHR is resveratrol, the "heart healthy" component of red wine.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Priscilla Jaichander, Krithika Selvarajan, Mahdi Garelnabi and Sampath Parthasarathy. Induction of paraoxonase 1 and apolipoprotein A1 gene expression by aspirin. Journal of Lipid Research, October, 2008 [link]

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Aspirin And Atherosclerosis: Mechanism Uncovered." ScienceDaily. ScienceDaily, 25 September 2008. <www.sciencedaily.com/releases/2008/09/080922155916.htm>.
American Society for Biochemistry and Molecular Biology. (2008, September 25). Aspirin And Atherosclerosis: Mechanism Uncovered. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/09/080922155916.htm
American Society for Biochemistry and Molecular Biology. "Aspirin And Atherosclerosis: Mechanism Uncovered." ScienceDaily. www.sciencedaily.com/releases/2008/09/080922155916.htm (accessed March 30, 2015).

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