Featured Research

from universities, journals, and other organizations

What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?

Date:
September 24, 2008
Source:
World Journal of Gastroenterology
Summary:
Scientists from China have isolated CD44+CD24+ subpopulation cells which have properties of tumor stem cells. Because cancer stem cells are thought to be responsible for tumor initiation, it may be a very promising target for new drug developments.

Pancreatic carcinoma is an obstinate disease that is difficult to deal with, the five-year survival rate is 4%. Conventional, the main treatments for pancreatic cancer are surgery, radiation therapy and chemotherapy. Despite advances in surgical and medical therapy, little effect has been made on the mortality rate of this disease.

The theory of tumor stem cells proposed that, the capacity of a tumor to grow and propagate is dependent on a small subset of cells (so-called tumor stem cells), the tumor stem cells are responsible for tumor formation and maintenance. If we may destroy these tumor stem cells, it will be possible to treat successfully tumors. The initial isolation and identification of tumor stem cells was first proved in hematological malignancies. However, it is difficult to purify tumor stem cells because of lack of specific cell surface markers in solid tumors.

Subsequently researchers have discovered a small population of cancer stem cells in several malignancies, including brain, prostate, liver, lung, melanoma, and colon tumors.

A research team leaded by CY Wang, described an isolation of a subset of PANC-1cells that expressed surface marker CD44 and CD24 which have properties of tumor stem cells.

Using an elegant study design, including flow cytometry analysis, a model of transplantation of cells, they found that CD44+ CD24+ cells have the biologial behaviors of lower proliferative index and faster tumor growth rate in vivo.

Further research should study further purification and other biological behaviors of pancreatic adenocarcinoma stem cells.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Huang et al. Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma. World Journal of Gastroenterology, 2008; 14 (24): 3903 DOI: 10.3748/wjg.14.3903

Cite This Page:

World Journal of Gastroenterology. "What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080924111153.htm>.
World Journal of Gastroenterology. (2008, September 24). What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2008/09/080924111153.htm
World Journal of Gastroenterology. "What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080924111153.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins