Featured Research

from universities, journals, and other organizations

What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?

Date:
September 24, 2008
Source:
World Journal of Gastroenterology
Summary:
Scientists from China have isolated CD44+CD24+ subpopulation cells which have properties of tumor stem cells. Because cancer stem cells are thought to be responsible for tumor initiation, it may be a very promising target for new drug developments.

Pancreatic carcinoma is an obstinate disease that is difficult to deal with, the five-year survival rate is 4%. Conventional, the main treatments for pancreatic cancer are surgery, radiation therapy and chemotherapy. Despite advances in surgical and medical therapy, little effect has been made on the mortality rate of this disease.

The theory of tumor stem cells proposed that, the capacity of a tumor to grow and propagate is dependent on a small subset of cells (so-called tumor stem cells), the tumor stem cells are responsible for tumor formation and maintenance. If we may destroy these tumor stem cells, it will be possible to treat successfully tumors. The initial isolation and identification of tumor stem cells was first proved in hematological malignancies. However, it is difficult to purify tumor stem cells because of lack of specific cell surface markers in solid tumors.

Subsequently researchers have discovered a small population of cancer stem cells in several malignancies, including brain, prostate, liver, lung, melanoma, and colon tumors.

A research team leaded by CY Wang, described an isolation of a subset of PANC-1cells that expressed surface marker CD44 and CD24 which have properties of tumor stem cells.

Using an elegant study design, including flow cytometry analysis, a model of transplantation of cells, they found that CD44+ CD24+ cells have the biologial behaviors of lower proliferative index and faster tumor growth rate in vivo.

Further research should study further purification and other biological behaviors of pancreatic adenocarcinoma stem cells.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Huang et al. Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma. World Journal of Gastroenterology, 2008; 14 (24): 3903 DOI: 10.3748/wjg.14.3903

Cite This Page:

World Journal of Gastroenterology. "What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?." ScienceDaily. ScienceDaily, 24 September 2008. <www.sciencedaily.com/releases/2008/09/080924111153.htm>.
World Journal of Gastroenterology. (2008, September 24). What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/09/080924111153.htm
World Journal of Gastroenterology. "What Is The Biological Feature Of Pancreatic Adenocarcinoma Stem Cells?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080924111153.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins