Featured Research

from universities, journals, and other organizations

Naturally Occurring 'Protective RNA' Used To Develop New Antiviral Against Influenza

Date:
September 30, 2008
Source:
American Society for Microbiology
Summary:
Researchers have developed a new antiviral using naturally occurring influenza virus "protecting virus" that may defend against any influenza A virus in any animal host.

Researchers from the University of Warwick, Coventry, United Kingdom have developed a new antiviral using naturally occurring influenza virus "protecting virus" that may defend against any influenza A virus in any animal host.

Human influenza virus A is not only responsible for seasonal disease in humans, it is also the cause of worldwide pandemics of which the last three resulted in millions of deaths all over the globe. Currently, live and killed vaccines countering specific strains of the flu are available, however a vaccine for a new pandemic strain would take months to develop. Also, increased resistance to antivirals currently on the market has emphasized the need for a new effective prophylactic and therapeutic treatment method.

The "protecting virus" contains an altered gene that makes it harmless and prevents it from reproducing in a cell. If another influenza virus invades the cell it still remains harmless, but rapidly reproduces and prevents infection by literally crowding out the new influenza strain.

In the study researchers used a "protecting virus" (known as 244) as an influenza A antiviral therapy and tested it in mice. A 120-ng intranasal dose completely protected mice simultaneously challenged with 10 50% lethal doses of influenza A/WSN (H1N1) virus. The 244 protecting virus also protected mice against strong doses of H2N2, H3N2, and H3N8.

Prophylactic activity was maintained in mice at least 1 week prior to challenge and a clear therapeutic benefit was observed when administered 24 to 48 hours following a lethal challenge. Finally, the 244 protecting virus was noted to be 10- to 100-fold more active than previous defective influenza A viruses.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dimmock et al. Influenza Virus Protecting RNA: an Effective Prophylactic and Therapeutic Antiviral. Journal of Virology, 2008; 82 (17): 8570 DOI: 10.1128/JVI.00743-08

Cite This Page:

American Society for Microbiology. "Naturally Occurring 'Protective RNA' Used To Develop New Antiviral Against Influenza." ScienceDaily. ScienceDaily, 30 September 2008. <www.sciencedaily.com/releases/2008/09/080926143749.htm>.
American Society for Microbiology. (2008, September 30). Naturally Occurring 'Protective RNA' Used To Develop New Antiviral Against Influenza. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/09/080926143749.htm
American Society for Microbiology. "Naturally Occurring 'Protective RNA' Used To Develop New Antiviral Against Influenza." ScienceDaily. www.sciencedaily.com/releases/2008/09/080926143749.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins